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• W2089776876 startingPage "129" @default.
• W2089776876 abstract "In an attempt to study the possible role of active sleep in brain development, male rats were injected twice daily with chlorimipramine, a potent monoamine reuptake blocker, from 1 week to 3 weeks of postnatal age. AS was reduced to less than 10% of total sleep time, the level found in mature rats. Most of the AS reduction was compensated for by quiet sleep but a slight increase in wakefulness also occurred, owing to brief interruptions of sleep at times when AS was expected. In adulthood, the AS-deprived rats showed a higher percentage of AS than did the controls, due to an increase in frequency and duration of AS epochs. Moreover, many of the epochs contained abnormally frequent and strong jerky body movements and rapid-eye-movements, reminiscent of neonatal AS patterns. In addition, the amplitude of hippocampal θ waves during AS was greater than in control rats. The chlorimipramine-treated rats also showed behavioral abnormalities in later life. On theopen field test exploratory behavior was much reduced, while increased rearing and defecation occurred. Masculinesexual performance was severely deficient, primarily due to the low level of intromissions and ejaculations. Experimental animals performed less efficiently than controls on atemporal learning task (differential reinforcement of low response rate) and responded more rapidly on aspatial task (left-right alternation learning). These results demonstrate that early interference with the functioning of monoaminergic systems can have long-lasting physiological and behavioral consequences. Furthermore, they are consistent with the hypothesis that AS is an important factor in normal brain development." @default.
• W2089776876 created "2016-06-24" @default.
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• W2089776876 date "1981-01-01" @default.
• W2089776876 modified "2023-09-26" @default.
• W2089776876 title "Suppression of active sleep by chronic treatment with chlorimipramine during early postnatal development: Effects upon adult sleep and behavior in the rat" @default.
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• W2089776876 doi "https://doi.org/10.1016/0006-8993(81)90657-0" @default.
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