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• W2089779474 abstract "2.5 mg lynestrenol-14C (Lyn), 2.0 mg cyproterone acetate-14C (CPA) and 0.25 mg d-norgestrel-3H (d-Ng), each together with 50μg ethinyloestradiol, were each administered once — consecutively in a randomised sequence — orally to 6 women. The substance combinations were administered as a micronisate with lactose in gelatine capsules at intervals of 14 days. The course of the substance concentration (NET for Lyn) and of the total radioactivity in plasma, and the elimination of the labelled substances were recorded up to the 5th and 8th day after ingestion. The progestogens were absorbed completely and at a comparable rate. The respective postmaximum course of the substance level in plasma was characterized by two disposition phases, of which the first phase with a half-life of about 3 hours displayed no substance-specific differences. Significant differences in the pharmacokinetics of the three progestogens could be demonstrated in the rate of the terminal disposition of the active substance (NET >d-Ng >CPA) and total radioactivity in plasma (d-Ng, CPA >Lyn), in the rate of elimination with urine and faeces (Lyn, d-Ng >CPA) and in the portion of the dose eliminated with the urine (d-Ng, Lyn >CPA) and faeces (CPA >d-Ng >Lyn)." @default.
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• W2089779474 date "1977-08-01" @default.
• W2089779474 modified "2023-09-25" @default.
• W2089779474 title "Intraindividual comparison of pharmacokinetic parameters of d-norgestrel, lynestrenol and cyproterone acetate in 6 women" @default.
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• W2089779474 doi "https://doi.org/10.1016/0010-7824(77)90087-7" @default.
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