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- W2089783288 abstract "ABSTRACT It is well known that topical exposure to sulfur mustard (SM) produces persistent, incapacitating blisters of the skin. However, the primary lesions effecting epidermal-dermal separation and disabling of mechanisms for cutaneous repair remain uncertain. Immunofluorescent staining plus multiphoton imaging of human epidermal tissues and keratinocytes exposed to SM (400 M x 5 min) have revealed that SM disrupts adhesion-complex molecules which are also disrupted by epidermolysis bullosa-type blistering diseases of the skin. Images of keratin-14 showed early, progressive, postexposure collapse of the K5/K14 cytoskeleton that resulted in ventral displacement of the nuclei beneath its collapsing filaments. This effectively corrupted the dynamic filament assemblies that link basal-cell nuclei to the extracellular matrix via 6 4 -integrin and laminin-5. At 1 h postexposure, there was disruption in the surface organization of 6 4 integrins, associated displacement of laminin-5 anchoring sites and a concomitant loss of functional asymmetry. Accordingly, our multiphoton images are providing compelling evidence that SM induces prevesicating lesions that disrupt the receptor-ligand organization and cytoskeletal systems required for maintaining dermal-epidermal attachment, signal transduction, and polarized mobility. Keywords: Sulfur mustard, blisters, human epidermis, keratin 14," @default.
- W2089783288 created "2016-06-24" @default.
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- W2089783288 date "2003-07-09" @default.
- W2089783288 modified "2023-09-23" @default.
- W2089783288 title "Multiphoton imaging: a view to understanding sulfur mustard lesions" @default.
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- W2089783288 doi "https://doi.org/10.1117/12.478035" @default.
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