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• W2089790148 abstract "The positivity for four cytochemical reactions, acid phosphatase (AcP), alpha-naphtyl acid acetate esterase (ANAE), beta-glucuronidase (BG), and N-acetyl beta-glucosaminidase (NABG) was correlated to first remission duration in 120 children affected with non-T, non-B acute lymphoblastic leukemia (ALL). The percentages of patients remaining in complete remission at 72 months were always higher for children whose blasts lacked these enzymatic reactions; however, a statistical difference was found only between BG+ and BG- ALL. It also appears that more complete enzymatic patterns of leukemic cells are associated with a poorer prognosis. The percentage of patients still in their first remission was 89% for leukemias with no cytochemical markers, 59% when one reaction was present, but less than 39% when two or more enzymes were detected in the blasts. It is noteworthy that the blasts of patients with more severe prognosis demonstrated a simultaneous positivity for AcP-ANAE or BG-NABG cytochemical reactions. The possible usefulness of these cytochemical markers to detect subsets of patients with different prognostic significance among non-T, non-B ALL is discussed." @default.
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• W2089790148 date "1984-09-15" @default.
• W2089790148 modified "2023-10-14" @default.
• W2089790148 title "Non-T, non-B childhood acute lymphoblastic leukemia. Correlation between cytochemical markers and first complete remission" @default.
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• W2089790148 doi "https://doi.org/10.1002/1097-0142(19840915)54:6<981::aid-cncr2820540606>3.0.co;2-y" @default.
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