FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089810978> ?p ?o ?g. }

• W2089810978 abstract "The effects of subcutaneous dosing of neonatal CD-1 mice with tamoxifen on days 1-5 after birth at doses of 0, 5, 10, 25 or 50 microg/pup or with 4-hydroxyoestradiol at 2 microg/pup have been investigated. Animals were culled at 1.5, 3, 6, 12 and 18 months after dosing and changes in uterine and ovarian pathology examined. Results showed both compounds to result in uterine hypoplasia relative to controls. At 18 months after dosing in the uterus, there was a fairly marked atrophy of the muscle layer, mild to moderate glandular hyperplasia of the endometrium even though these irregularly shaped glands did not penetrate through the myometrium and no adenocarcinomas were detected. At 18 months after dosing, oviducts showed mild focal adenomatous changes characterized by penetration epithelial hyperplasia, changes similar to those previously reported as 'diverticulosis and salpingitis isthmica nodosa' following diethylstilbestrol treatment of mice. At this time, both tamoxifen and 4-hydroxyoestradiol also affected the ovaries which showed a paucity of follicles and no corpora lutea, suggesting that there had been disruption to the oestrus cycle, particularly with tamoxifen at the highest dose where the ovaries of mice contained no developing follicles. At 18 months, control mice were cycling normally. Results failed to substantiate that tamoxifen and 4-hydroxyoestradiol are uterine carcinogens in this neonatal mouse model." @default.
• W2089810978 created "2016-06-24" @default.
• W2089810978 creator A5009712577 @default.
• W2089810978 creator A5039024766 @default.
• W2089810978 creator A5050670968 @default.
• W2089810978 creator A5052338995 @default.
• W2089810978 creator A5053371660 @default.
• W2089810978 date "2007-11-01" @default.
• W2089810978 modified "2023-10-14" @default.
• W2089810978 title "Absence of uterine tumours in CD-1 mice treated neonatally with subcutaneous tamoxifen or 4-hydroxyoestradiol" @default.
• W2089810978 cites W144597090 @default.
• W2089810978 cites W1608964217 @default.
• W2089810978 cites W1670696213 @default.
• W2089810978 cites W1790333224 @default.
• W2089810978 cites W1971862881 @default.
• W2089810978 cites W1974833603 @default.
• W2089810978 cites W2014333106 @default.
• W2089810978 cites W2018575000 @default.
• W2089810978 cites W2019788718 @default.
• W2089810978 cites W2033013228 @default.
• W2089810978 cites W2040228565 @default.
• W2089810978 cites W2041258563 @default.
• W2089810978 cites W2043636561 @default.
• W2089810978 cites W2043652943 @default.
• W2089810978 cites W2050569905 @default.
• W2089810978 cites W2075521327 @default.
• W2089810978 cites W2078947463 @default.
• W2089810978 cites W2083440063 @default.
• W2089810978 cites W2127349594 @default.
• W2089810978 cites W2145935663 @default.
• W2089810978 cites W2149944230 @default.
• W2089810978 cites W2153265041 @default.
• W2089810978 cites W2154377786 @default.
• W2089810978 cites W2155481621 @default.
• W2089810978 cites W2160016510 @default.
• W2089810978 cites W2166969772 @default.
• W2089810978 cites W2172185687 @default.
• W2089810978 cites W2406420759 @default.
• W2089810978 cites W2419278362 @default.
• W2089810978 cites W330388444 @default.
• W2089810978 doi "https://doi.org/10.1016/j.etp.2007.06.002" @default.
• W2089810978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17825543" @default.
• W2089810978 hasPublicationYear "2007" @default.
• W2089810978 type Work @default.
• W2089810978 sameAs 2089810978 @default.
• W2089810978 citedByCount "3" @default.
• W2089810978 countsByYear W20898109782012 @default.
• W2089810978 countsByYear W20898109782013 @default.
• W2089810978 countsByYear W20898109782015 @default.
• W2089810978 crossrefType "journal-article" @default.
• W2089810978 hasAuthorship W2089810978A5009712577 @default.
• W2089810978 hasAuthorship W2089810978A5039024766 @default.
• W2089810978 hasAuthorship W2089810978A5050670968 @default.
• W2089810978 hasAuthorship W2089810978A5052338995 @default.
• W2089810978 hasAuthorship W2089810978A5053371660 @default.
• W2089810978 hasConcept C121608353 @default.
• W2089810978 hasConcept C126322002 @default.
• W2089810978 hasConcept C134018914 @default.
• W2089810978 hasConcept C1998276 @default.
• W2089810978 hasConcept C2777164284 @default.
• W2089810978 hasConcept C2777176818 @default.
• W2089810978 hasConcept C2777562237 @default.
• W2089810978 hasConcept C2778164554 @default.
• W2089810978 hasConcept C2778324911 @default.
• W2089810978 hasConcept C2779066055 @default.
• W2089810978 hasConcept C2779742232 @default.
• W2089810978 hasConcept C2781397067 @default.
• W2089810978 hasConcept C530470458 @default.
• W2089810978 hasConcept C71924100 @default.
• W2089810978 hasConcept C86803240 @default.
• W2089810978 hasConceptScore W2089810978C121608353 @default.
• W2089810978 hasConceptScore W2089810978C126322002 @default.
• W2089810978 hasConceptScore W2089810978C134018914 @default.
• W2089810978 hasConceptScore W2089810978C1998276 @default.
• W2089810978 hasConceptScore W2089810978C2777164284 @default.
• W2089810978 hasConceptScore W2089810978C2777176818 @default.
• W2089810978 hasConceptScore W2089810978C2777562237 @default.
• W2089810978 hasConceptScore W2089810978C2778164554 @default.
• W2089810978 hasConceptScore W2089810978C2778324911 @default.
• W2089810978 hasConceptScore W2089810978C2779066055 @default.
• W2089810978 hasConceptScore W2089810978C2779742232 @default.
• W2089810978 hasConceptScore W2089810978C2781397067 @default.
• W2089810978 hasConceptScore W2089810978C530470458 @default.
• W2089810978 hasConceptScore W2089810978C71924100 @default.
• W2089810978 hasConceptScore W2089810978C86803240 @default.
• W2089810978 hasLocation W20898109781 @default.
• W2089810978 hasLocation W20898109782 @default.
• W2089810978 hasOpenAccess W2089810978 @default.
• W2089810978 hasPrimaryLocation W20898109781 @default.
• W2089810978 hasRelatedWork W1976313277 @default.
• W2089810978 hasRelatedWork W2019385954 @default.
• W2089810978 hasRelatedWork W2053749919 @default.
• W2089810978 hasRelatedWork W2068976714 @default.
• W2089810978 hasRelatedWork W2172113835 @default.
• W2089810978 hasRelatedWork W2292440465 @default.
• W2089810978 hasRelatedWork W2365056534 @default.
• W2089810978 hasRelatedWork W2367132161 @default.
• W2089810978 hasRelatedWork W2410301123 @default.
• W2089810978 hasRelatedWork W3002300369 @default.
• W2089810978 isParatext "false" @default.

• next