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• W2089813503 startingPage "1325" @default.
• W2089813503 abstract "It has been reported that the hippocampus is particularly vulnerable to traumatic brain injury (TBI), the consequence of which results in hippocampal-dependent cognitive impairment. In the previous study we found that adult-born immature neurons in the hippocampal dentate gyrus are the most vulnerable cell type to moderate TBI insult. However, the molecular mechanisms that regulate the survival of adult-born immature neurons in the hippocampus following TBI are still not well understood. Here, we conditionally knocked out brain-derived neurotrophic factor (BDNF) in the hippocampal dentate gyrus and examined the death of adult-born immature neurons following moderate TBI. The results showed that the amount of adult-born immature neuron death in the hippocampal dentate gyrus significantly increased in the BDNF conditional knockout mice. This result suggests that BDNF is involved in regulating the survival of adult-born immature neurons in the hippocampus following TBI, and potentially might be a useful target for preventing the adult-born immature neurons from death following TBI." @default.
• W2089813503 created "2016-06-24" @default.
• W2089813503 creator A5014021506 @default.
• W2089813503 creator A5066406371 @default.
• W2089813503 date "2009-08-01" @default.
• W2089813503 modified "2023-10-14" @default.
• W2089813503 title "Conditional Knockout of Brain-Derived Neurotrophic Factor in the Hippocampus Increases Death of Adult-Born Immature Neurons following Traumatic Brain Injury" @default.
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• W2089813503 doi "https://doi.org/10.1089/neu.2008.0744" @default.
• W2089813503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19203227" @default.
• W2089813503 hasPublicationYear "2009" @default.
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