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- W2089817764 abstract "The dorsal lateral geniculate nucleus (LGN) is the major thalamic relay for retinal signals en route to cortex. However, LGN cells operate as more than just a simple relay of their retinal inputs. Rather, they function as a variable gate, determining what, when, and how much retinal information gets passed to visual cortex. Two factors that are key to this control are the innervation patterns and electrophysiological membrane properties of geniculate cells. This paper discusses three active membrane properties and the manner in which they modulate the transfer of retinal signals to cortex. They are the low threshold calcium (Ca2+) conductance, a transient potassium (K+) conductance, and NMDA receptor-mediated excitatory postsynaptic potentials (EPSPs). The low-threshold Ca2+ conductance transforms a geniculate cell from a state of single spike activity to one of bursting discharge, the potassium current leads to a delay in membrane depolarization to reach spike threshold, and NMDA receptor activity modulates EPSP amplitude and duration near spike threshold. Additionally, we consider how nonretinal inputs, such as the ascending cholinergic pathway from the brainstem parabrachial region and the descending pathway from layer VI of visual cortex, influence the expression of these membrane properties through their control of membrane potential." @default.
- W2089817764 created "2016-06-24" @default.
- W2089817764 creator A5044038365 @default.
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- W2089817764 date "1995-01-01" @default.
- W2089817764 modified "2023-09-23" @default.
- W2089817764 title "Cellular bases for the control of retinogeniculate signal transmission" @default.
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- W2089817764 doi "https://doi.org/10.3109/00207459508986093" @default.
- W2089817764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7775060" @default.
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