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- W2089833068 abstract "Abstract A number of novel enediyne compounds such as 3 equipped with a 2-(phenylsulfonyl)ethoxycarbonyl protecting group on the nitrogen atom have demonstrated selective cutotoxicity against a variety of cancer cell lines. Compounds 4–6 possessing one or two methyl group(s) at the C2 position of the sulfone residue have been synthesized and tested, showing reduced cytotoxity as compared to 3 , suggesting that a β-elimination mechanism as the main initial step for the activation of these cytotoxic agents. The differential in the cytotoxicity of compounds 4 and 5 with opposite chirality at C2 suggests the possible existence of tumor-associated factors in certain tumor cells that may activate these systems selectively." @default.
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- W2089833068 date "1992-09-01" @default.
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- W2089833068 title "On the mechanism of activation of designed enediynes with selective cytotoxicity" @default.
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- W2089833068 doi "https://doi.org/10.1016/s0960-894x(00)80638-1" @default.
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