FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089843092> ?p ?o ?g. }

• W2089843092 endingPage "294" @default.
• W2089843092 startingPage "287" @default.
• W2089843092 abstract "Isolates of viral haemorrhagic septicaemia virus (VHSV) were identified which are genetically similar yet, based on their isolation history were considered likely to differ in virulence in juvenile rainbow trout. An experimental infection study was performed in order to verify this hypothesis and provide an experimental infectivity model with which to investigate the basis for susceptibility of rainbow trout to this commercially important virus. Significant differences in mortality were obtained following both intraperitoneal (IP) injection and immersion challenges with an early marine (DK-M.Rhabdo) and early rainbow trout VHSV isolate (DK-F1) respectively. Expression of Type I IFN, Mx1 (an IFN-inducible protein), and viral genes (encoding nucleo-, phospho-, matrix, glyco- and non-viron proteins) was studied in sequential tissue samples using real-time quantitative PCR (QPCR). Resulting data revealed a significant increase in IFN and Mx1 expression detected in fish challenged by IP injection with both isolates. Expression levels of these genes were directly related to the degree of viral replication as measured by the expression of VHSV RNAs. In immersion-challenged fish a significant increase in Mx1 was observed only when using the virulent isolate DK-F1; however no elevated host response was detectable in fish challenged with the marine isolate DK-M.Rhabdo. Quintessentially the inability to detect any virus in trout challenged with the marine isolate via immersion suggests the virus was incapable of establishing infection. The mechanisms for this appear to be more related to initial cellular entry and replication rather than due to the overcoming of initial infection via an elevated host innate immune response." @default.
• W2089843092 created "2016-06-24" @default.
• W2089843092 creator A5008583465 @default.
• W2089843092 creator A5012214121 @default.
• W2089843092 creator A5027523820 @default.
• W2089843092 creator A5063968534 @default.
• W2089843092 creator A5073964024 @default.
• W2089843092 date "2011-01-01" @default.
• W2089843092 modified "2023-09-23" @default.
• W2089843092 title "Interferon response following infection with genetically similar isolates of viral haemorrhagic septicaemia virus (VHSV) exhibiting contrasting virulence in rainbow trout" @default.
• W2089843092 cites W1490200235 @default.
• W2089843092 cites W1534180034 @default.
• W2089843092 cites W153943130 @default.
• W2089843092 cites W1707777570 @default.
• W2089843092 cites W1735815967 @default.
• W2089843092 cites W1971530944 @default.
• W2089843092 cites W1976365335 @default.
• W2089843092 cites W1978291347 @default.
• W2089843092 cites W1983779089 @default.
• W2089843092 cites W1985050849 @default.
• W2089843092 cites W1985721934 @default.
• W2089843092 cites W1986762728 @default.
• W2089843092 cites W1997814738 @default.
• W2089843092 cites W1997939418 @default.
• W2089843092 cites W2002706411 @default.
• W2089843092 cites W2007232879 @default.
• W2089843092 cites W2007450246 @default.
• W2089843092 cites W2011903133 @default.
• W2089843092 cites W2013648574 @default.
• W2089843092 cites W2022862669 @default.
• W2089843092 cites W2023024586 @default.
• W2089843092 cites W2026144226 @default.
• W2089843092 cites W2039370080 @default.
• W2089843092 cites W2046356856 @default.
• W2089843092 cites W2050438864 @default.
• W2089843092 cites W2058934410 @default.
• W2089843092 cites W2059419113 @default.
• W2089843092 cites W2061227883 @default.
• W2089843092 cites W2069305021 @default.
• W2089843092 cites W2075841279 @default.
• W2089843092 cites W2080093693 @default.
• W2089843092 cites W2083773668 @default.
• W2089843092 cites W2091843987 @default.
• W2089843092 cites W2093354566 @default.
• W2089843092 cites W2106870928 @default.
• W2089843092 cites W2109190998 @default.
• W2089843092 cites W2112095981 @default.
• W2089843092 cites W2115794252 @default.
• W2089843092 cites W2117688322 @default.
• W2089843092 cites W2125337655 @default.
• W2089843092 cites W2131798409 @default.
• W2089843092 cites W2133948559 @default.
• W2089843092 cites W2144734658 @default.
• W2089843092 cites W2149813463 @default.
• W2089843092 cites W2150598751 @default.
• W2089843092 cites W2153049954 @default.
• W2089843092 cites W2158048272 @default.
• W2089843092 cites W2175998193 @default.
• W2089843092 cites W2240157516 @default.
• W2089843092 cites W2256756668 @default.
• W2089843092 cites W2518334444 @default.
• W2089843092 cites W2555837248 @default.
• W2089843092 cites W3163348161 @default.
• W2089843092 cites W3046078369 @default.
• W2089843092 doi "https://doi.org/10.1016/j.fsi.2010.10.021" @default.
• W2089843092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21056106" @default.
• W2089843092 hasPublicationYear "2011" @default.
• W2089843092 type Work @default.
• W2089843092 sameAs 2089843092 @default.
• W2089843092 citedByCount "21" @default.
• W2089843092 countsByYear W20898430922012 @default.
• W2089843092 countsByYear W20898430922013 @default.
• W2089843092 countsByYear W20898430922014 @default.
• W2089843092 countsByYear W20898430922015 @default.
• W2089843092 countsByYear W20898430922016 @default.
• W2089843092 countsByYear W20898430922017 @default.
• W2089843092 countsByYear W20898430922018 @default.
• W2089843092 countsByYear W20898430922021 @default.
• W2089843092 countsByYear W20898430922022 @default.
• W2089843092 crossrefType "journal-article" @default.
• W2089843092 hasAuthorship W2089843092A5008583465 @default.
• W2089843092 hasAuthorship W2089843092A5012214121 @default.
• W2089843092 hasAuthorship W2089843092A5027523820 @default.
• W2089843092 hasAuthorship W2089843092A5063968534 @default.
• W2089843092 hasAuthorship W2089843092A5073964024 @default.
• W2089843092 hasConcept C104317684 @default.
• W2089843092 hasConcept C106358424 @default.
• W2089843092 hasConcept C140704245 @default.
• W2089843092 hasConcept C159047783 @default.
• W2089843092 hasConcept C2522874641 @default.
• W2089843092 hasConcept C2776178377 @default.
• W2089843092 hasConcept C2779363728 @default.
• W2089843092 hasConcept C2909208804 @default.
• W2089843092 hasConcept C2994167347 @default.
• W2089843092 hasConcept C505870484 @default.
• W2089843092 hasConcept C54355233 @default.
• W2089843092 hasConcept C60987743 @default.
• W2089843092 hasConcept C86803240 @default.

• next