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- W2089846934 endingPage "699" @default.
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- W2089846934 abstract "A series of charge-reversal lipids were synthesized that possess varying chain lengths and end functionalities. These lipids were designed to bind and then release DNA based on a change in electrostatic interaction with DNA. Specifically, a cleavable ester linkage is located at the ends of the hydrocarbon chains. The DNA release from the amphiphile was tuned by altering the length and position of the ester linkage in the hydrophobic chains of the lipids through the preparation of five new amphiphiles. The amphiphiles and corresponding lipoplexes were characterized by DSC, TEM, and X-ray, as well as evaluated for DNA binding and DNA transfection. For one specific charge-reversal lipid, stable lipoplexes of approximately 550 nm were formed, and with this amphiphile, effective in vitro DNA transfection activities was observed." @default.
- W2089846934 created "2016-06-24" @default.
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- W2089846934 creator A5062228665 @default.
- W2089846934 creator A5080271438 @default.
- W2089846934 date "2011-04-01" @default.
- W2089846934 modified "2023-10-17" @default.
- W2089846934 title "Synthesis, Characterization, and <i>In Vitro</i> Transfection Activity of Charge-Reversal Amphiphiles for DNA Delivery" @default.
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- W2089846934 doi "https://doi.org/10.1021/bc1004526" @default.
- W2089846934 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3878859" @default.
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- W2089846934 hasPublicationYear "2011" @default.
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