Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089863905> ?p ?o ?g. }
- W2089863905 endingPage "e969653" @default.
- W2089863905 startingPage "e969653" @default.
- W2089863905 abstract "p53, the revered savior of genomic integrity, receives signals from diverse stress sensors and strategizes to maintain cellular homeostasis. However, the predominance of p53 overshadows the fact that this herculean task is no one-man show; rather, there is a huge army of regulators that reign over p53 at various levels to avoid an unnecessary surge in its levels and sculpt it dynamically to favor one cellular outcome over another. This governance starts right at the time of p53 translation, which is gated by proteins that bind to p53 mRNA and keep a stringent check on p53 protein levels. The same effect is also achieved by ubiquitylases and deubiquitylases that fine-tune p53 turnover and miRNAs that modulate p53 levels, adding precision to this entire scheme. In addition, extensive covalent modifications and differential protein interactions allow p53 to trigger a tailor-made response for a given circumstance. To magnify the marvel, these various tiers of regulation operate simultaneously and in various combinations. In this review, we have tried to provide a glimpse into this bewildering labyrinth. We believe that further studies will result in a better understanding of p53 regulation and that new insights will help unravel many aspects of cancer biology." @default.
- W2089863905 created "2016-06-24" @default.
- W2089863905 creator A5017504867 @default.
- W2089863905 creator A5059405598 @default.
- W2089863905 creator A5083613634 @default.
- W2089863905 date "2014-09-15" @default.
- W2089863905 modified "2023-09-27" @default.
- W2089863905 title "p53 regulation upon genotoxic stress: intricacies and complexities" @default.
- W2089863905 cites W1495729285 @default.
- W2089863905 cites W1497941038 @default.
- W2089863905 cites W1498388726 @default.
- W2089863905 cites W1563316806 @default.
- W2089863905 cites W1606671377 @default.
- W2089863905 cites W1923756169 @default.
- W2089863905 cites W1950155832 @default.
- W2089863905 cites W1963795701 @default.
- W2089863905 cites W1968220278 @default.
- W2089863905 cites W1969250771 @default.
- W2089863905 cites W1975089320 @default.
- W2089863905 cites W1976907433 @default.
- W2089863905 cites W1981665139 @default.
- W2089863905 cites W1982545065 @default.
- W2089863905 cites W1988302225 @default.
- W2089863905 cites W1989705133 @default.
- W2089863905 cites W1989873806 @default.
- W2089863905 cites W1992140922 @default.
- W2089863905 cites W1993720756 @default.
- W2089863905 cites W1995741673 @default.
- W2089863905 cites W1996992777 @default.
- W2089863905 cites W1998577031 @default.
- W2089863905 cites W1999266701 @default.
- W2089863905 cites W1999598905 @default.
- W2089863905 cites W2002689109 @default.
- W2089863905 cites W2005109475 @default.
- W2089863905 cites W2006173503 @default.
- W2089863905 cites W2006413040 @default.
- W2089863905 cites W2007249806 @default.
- W2089863905 cites W2012753961 @default.
- W2089863905 cites W2013721931 @default.
- W2089863905 cites W2014397238 @default.
- W2089863905 cites W2017673293 @default.
- W2089863905 cites W2018639404 @default.
- W2089863905 cites W2020536449 @default.
- W2089863905 cites W2022162825 @default.
- W2089863905 cites W2025476423 @default.
- W2089863905 cites W2027548638 @default.
- W2089863905 cites W2029690067 @default.
- W2089863905 cites W2030048487 @default.
- W2089863905 cites W2032076692 @default.
- W2089863905 cites W2032623282 @default.
- W2089863905 cites W2035828746 @default.
- W2089863905 cites W2038324148 @default.
- W2089863905 cites W2038968612 @default.
- W2089863905 cites W2039463309 @default.
- W2089863905 cites W2040331457 @default.
- W2089863905 cites W2049436772 @default.
- W2089863905 cites W2050745715 @default.
- W2089863905 cites W2052887017 @default.
- W2089863905 cites W2053195920 @default.
- W2089863905 cites W2054311839 @default.
- W2089863905 cites W2061104522 @default.
- W2089863905 cites W2062976534 @default.
- W2089863905 cites W2064715144 @default.
- W2089863905 cites W2064768081 @default.
- W2089863905 cites W2065886319 @default.
- W2089863905 cites W2071555702 @default.
- W2089863905 cites W2072677280 @default.
- W2089863905 cites W2073631639 @default.
- W2089863905 cites W2074292065 @default.
- W2089863905 cites W2075213054 @default.
- W2089863905 cites W2077212116 @default.
- W2089863905 cites W2077229666 @default.
- W2089863905 cites W2081667575 @default.
- W2089863905 cites W2083550053 @default.
- W2089863905 cites W2086180957 @default.
- W2089863905 cites W2087732778 @default.
- W2089863905 cites W2090759673 @default.
- W2089863905 cites W2091818021 @default.
- W2089863905 cites W2092108176 @default.
- W2089863905 cites W2093662097 @default.
- W2089863905 cites W2095899172 @default.
- W2089863905 cites W2096268559 @default.
- W2089863905 cites W2101085456 @default.
- W2089863905 cites W2104014368 @default.
- W2089863905 cites W2105777529 @default.
- W2089863905 cites W2109377963 @default.
- W2089863905 cites W2109511371 @default.
- W2089863905 cites W2111772438 @default.
- W2089863905 cites W2111990378 @default.
- W2089863905 cites W2113239055 @default.
- W2089863905 cites W2120005985 @default.
- W2089863905 cites W2129750560 @default.
- W2089863905 cites W2133138889 @default.
- W2089863905 cites W2135387645 @default.
- W2089863905 cites W2138566050 @default.
- W2089863905 cites W2142780841 @default.
- W2089863905 cites W2143460288 @default.
- W2089863905 cites W2144919418 @default.