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- W2089872009 abstract "We examined the effects of a single exposure to the pancreatic carcinogen N-nitroso-bis-(2-hydroxypropyl)amine on pancreatic function in hamsters. In one group of 12 animals, the carcinogen was given intravenously, and pancreatic secretion was stimulated with secretin or CCK 1 hr later. In five other groups, secretion was stimulated 24 hr, 1, 2, 4, or 8 weeks after the carcinogen was given. We found that the bicarbonate concentration of pancreatic juice was increased as early as 1 hr after administration of carcinogen, and that the increase persisted for 2 weeks. Protein concentration and output were depressed within 1 hr of carcinogen administration, but in 24 hr both were elevated above normal. This increase persisted for 8 weeks. Volume flow was not affected. These results prove that a single exposure to a known pancreatic carcinogen may have lasting effects on pancreatic function. They imply that a brief exposure to similar agents in humans could initiate major alterations in pancreatic morphology which might be premalignant." @default.
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- W2089872009 title "Effect of a single exposure to a carcinogen on pancreatic function in hamsters" @default.
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- W2089872009 doi "https://doi.org/10.1016/0022-4804(81)90066-4" @default.
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