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- W2089879345 abstract "Abstract Persistence is a hallmark of infection by viruses such as HIV, hepatitis B virus, hepatitis C virus and LCMV. In the case of LCMV, persistence may often be associated with exhaustion of CD8 + T cells. We demonstrate here that persistent antigen suppressed IL‐7Rα expression and this correlated with T cell exhaustion and reduced expression of the anti‐apoptotic molecule B cell leukemia/lymphoma 2 (Bcl‐2). In contrast, exposure to short‐lived antigen only temporarily suppressed IL‐7Rα expression, failed to induce T cell exhaustion, and primed T cells. Persistent antigen also suppressed IL‐7Rα expression on primed T cells and this correlated with exhaustion of a previously stable primed T cell population. These findings suggest that antigen longevity regulates T cell fate." @default.
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- W2089879345 date "2005-02-22" @default.
- W2089879345 modified "2023-10-11" @default.
- W2089879345 title "Inverse correlation between IL-7 receptor expression and CD8 T cell exhaustion during persistent antigen stimulation" @default.
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- W2089879345 doi "https://doi.org/10.1002/eji.200425828" @default.
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