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- W2089882352 abstract "CD4⁺CD25⁺Foxp3⁺ T lymphocytes, known as regulatory T cells or T(regs), have been proposed to be a lineage of professional immune suppressive cells that exclusively counteract the effects of the immunoprotective helper and cytotoxic lineages of T lymphocytes. Here we discuss new concepts on the mechanisms and functions of T(regs). There are several key points we emphasize: 1. Tregs exert suppressive effects both directly on effector T cells and indirectly through antigen-presenting cells; 2. Regulation can occur through a novel mechanism of cytokine consumption to regulate as opposed to the usual mechanism of cytokine/chemokine production; 3. In cases where CD4⁺ effector T cells are directly inhibited by T(regs), it is chiefly through a mechanism of lymphokine withdrawal apoptosis leading to polyclonal deletion; and 4. Contrary to the current view, we discuss new evidence that T(regs), similar to other T-cells lineages, can promote protective immune responses in certain infectious contexts (Chen et al., 2011; Pandiyan et al., 2011). Although these points are at variance to varying degrees with the standard model of T(reg) behavior, we will recount developing findings that support these new concepts." @default.
- W2089882352 created "2016-06-24" @default.
- W2089882352 creator A5027391849 @default.
- W2089882352 creator A5088733725 @default.
- W2089882352 date "2011-01-01" @default.
- W2089882352 modified "2023-09-27" @default.
- W2089882352 title "The Molecular Mechanisms of Regulatory T Cell Immunosuppression" @default.
- W2089882352 cites W131805426 @default.
- W2089882352 cites W132916333 @default.
- W2089882352 cites W1486722793 @default.
- W2089882352 cites W1501512952 @default.
- W2089882352 cites W1516581843 @default.
- W2089882352 cites W1527526213 @default.
- W2089882352 cites W1530044612 @default.
- W2089882352 cites W1546288178 @default.
- W2089882352 cites W1553251559 @default.
- W2089882352 cites W1845629018 @default.
- W2089882352 cites W1856442459 @default.
- W2089882352 cites W1912001846 @default.
- W2089882352 cites W1918737925 @default.
- W2089882352 cites W1921076722 @default.
- W2089882352 cites W1922774027 @default.
- W2089882352 cites W1950049235 @default.
- W2089882352 cites W1964954988 @default.
- W2089882352 cites W1965673490 @default.
- W2089882352 cites W1966922635 @default.
- W2089882352 cites W1967261754 @default.
- W2089882352 cites W1967896457 @default.
- W2089882352 cites W1968274103 @default.
- W2089882352 cites W1971119469 @default.
- W2089882352 cites W1971782694 @default.
- W2089882352 cites W1972066347 @default.
- W2089882352 cites W1974535482 @default.
- W2089882352 cites W1975605578 @default.
- W2089882352 cites W1982226677 @default.
- W2089882352 cites W1984153640 @default.
- W2089882352 cites W1985630443 @default.
- W2089882352 cites W1987821468 @default.
- W2089882352 cites W1991036879 @default.
- W2089882352 cites W1993621815 @default.
- W2089882352 cites W1996532235 @default.
- W2089882352 cites W2000869878 @default.
- W2089882352 cites W2001740313 @default.
- W2089882352 cites W2001809800 @default.
- W2089882352 cites W2006756007 @default.
- W2089882352 cites W2006877529 @default.
- W2089882352 cites W2009649988 @default.
- W2089882352 cites W2010244581 @default.
- W2089882352 cites W2011736381 @default.
- W2089882352 cites W2017893786 @default.
- W2089882352 cites W2018703348 @default.
- W2089882352 cites W2019060341 @default.
- W2089882352 cites W2020976328 @default.
- W2089882352 cites W2021099643 @default.
- W2089882352 cites W2025761406 @default.
- W2089882352 cites W2029819700 @default.
- W2089882352 cites W2029836713 @default.
- W2089882352 cites W2030284768 @default.
- W2089882352 cites W2030682069 @default.
- W2089882352 cites W2034430001 @default.
- W2089882352 cites W2037061225 @default.
- W2089882352 cites W2038271225 @default.
- W2089882352 cites W2039467806 @default.
- W2089882352 cites W2043776488 @default.
- W2089882352 cites W2052919634 @default.
- W2089882352 cites W2057968168 @default.
- W2089882352 cites W2058401819 @default.
- W2089882352 cites W2059012075 @default.
- W2089882352 cites W2061071534 @default.
- W2089882352 cites W2067356055 @default.
- W2089882352 cites W2068318977 @default.
- W2089882352 cites W2068521142 @default.
- W2089882352 cites W2070706464 @default.
- W2089882352 cites W2070825285 @default.
- W2089882352 cites W2071909988 @default.
- W2089882352 cites W2073269063 @default.
- W2089882352 cites W2074341605 @default.
- W2089882352 cites W2075326117 @default.
- W2089882352 cites W2076510057 @default.
- W2089882352 cites W2076710136 @default.
- W2089882352 cites W2085350250 @default.
- W2089882352 cites W2087482409 @default.
- W2089882352 cites W2092786335 @default.
- W2089882352 cites W2099318980 @default.
- W2089882352 cites W2099845842 @default.
- W2089882352 cites W2101230909 @default.
- W2089882352 cites W2102202232 @default.
- W2089882352 cites W2103891140 @default.
- W2089882352 cites W2104680582 @default.
- W2089882352 cites W2105484520 @default.
- W2089882352 cites W2106910404 @default.
- W2089882352 cites W2109015336 @default.
- W2089882352 cites W2110491264 @default.
- W2089882352 cites W2111329034 @default.
- W2089882352 cites W2112506009 @default.
- W2089882352 cites W2117570533 @default.
- W2089882352 cites W2122979926 @default.
- W2089882352 cites W2123013608 @default.
- W2089882352 cites W2125311191 @default.
- W2089882352 cites W2125480339 @default.