FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089885055> ?p ?o ?g. }

• W2089885055 endingPage "201" @default.
• W2089885055 startingPage "197" @default.
• W2089885055 abstract "Numerous functional studies establish the role of nitric oxide (NO) as a neuromodulator in the central nervous system which affects synaptic transmission. However, there are only a few reports indicating a direct and postsynaptic effect of nitric oxide on the electrical activity of neurons in the central nervous system. The aim of this study was to characterize the effect of nitric oxide on spontaneously active neurons in spinal cord slices using an extracellular recording technique. Because in the lumbar rat spinal cord the NO producing enzyme NO-synthase is primarily located in the superficial dorsal horn (laminae I+II) and around the central canal (lamina X), we restricted our recordings to these areas. While the majority of neurons increased their electrical activity during superfusion with the NO-donor sodium nitroprusside (SNP) in lamina X, neurons in laminae I+II were mainly inhibited by SNP. The excitatory and the inhibitory effects were dose-dependent and reversible and were mimicked by other NO-donors and membrane permeable cyclic guanosine monophosphate (8Br-cGMP) on the same neurons. The spinal cord slice preparation contains functional NO-synthase (NOS), because selective blockade of NOS increased the spontaneous activity of those neurons from laminae I+II which were inhibited by SNP and this effect could be reversed by superfusion with the natural substrate for NOS, l-arginine. It is concluded that NO can activate and inhibit the activity of spinal cord neurons by raising cGMP levels and that these effects are lamina specific. A general consequence of our results is that the NO-induced production of cGMP alone does not allow any prediction about an excitatory or inhibitory effect of NO on the discharge rate of neurons. Thus the NO mediated increase and decrease in neuronal activity is probably the result of intracellular mechanisms downstream from the production of cGMP which results in the activation or inhibition of different ion channels on neurons in laminae I+II and X." @default.
• W2089885055 created "2016-06-24" @default.
• W2089885055 creator A5014263080 @default.
• W2089885055 creator A5083636719 @default.
• W2089885055 date "1996-06-01" @default.
• W2089885055 modified "2023-10-11" @default.
• W2089885055 title "Regional specific effects of nitric oxide donors and cGMP on the electrical activity of neurons in the rat spinal cord" @default.
• W2089885055 cites W1969869149 @default.
• W2089885055 cites W1975333295 @default.
• W2089885055 cites W1985172143 @default.
• W2089885055 cites W1986891292 @default.
• W2089885055 cites W1994714777 @default.
• W2089885055 cites W2012038403 @default.
• W2089885055 cites W2020819625 @default.
• W2089885055 cites W2021569785 @default.
• W2089885055 cites W2024862570 @default.
• W2089885055 cites W2032411573 @default.
• W2089885055 cites W2044628349 @default.
• W2089885055 cites W2049781967 @default.
• W2089885055 cites W2090346146 @default.
• W2089885055 cites W2107732949 @default.
• W2089885055 cites W2108498540 @default.
• W2089885055 cites W2124333932 @default.
• W2089885055 cites W2147944067 @default.
• W2089885055 cites W2149995120 @default.
• W2089885055 cites W2172527495 @default.
• W2089885055 doi "https://doi.org/10.1016/0891-0618(96)00143-3" @default.
• W2089885055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8811423" @default.
• W2089885055 hasPublicationYear "1996" @default.
• W2089885055 type Work @default.
• W2089885055 sameAs 2089885055 @default.
• W2089885055 citedByCount "29" @default.
• W2089885055 countsByYear W20898850552012 @default.
• W2089885055 countsByYear W20898850552015 @default.
• W2089885055 countsByYear W20898850552017 @default.
• W2089885055 countsByYear W20898850552022 @default.
• W2089885055 crossrefType "journal-article" @default.
• W2089885055 hasAuthorship W2089885055A5014263080 @default.
• W2089885055 hasAuthorship W2089885055A5083636719 @default.
• W2089885055 hasConcept C112592302 @default.
• W2089885055 hasConcept C169760540 @default.
• W2089885055 hasConcept C170493617 @default.
• W2089885055 hasConcept C17077164 @default.
• W2089885055 hasConcept C178790620 @default.
• W2089885055 hasConcept C185592680 @default.
• W2089885055 hasConcept C197341189 @default.
• W2089885055 hasConcept C200170125 @default.
• W2089885055 hasConcept C2777622882 @default.
• W2089885055 hasConcept C2779610285 @default.
• W2089885055 hasConcept C2780775167 @default.
• W2089885055 hasConcept C2780994212 @default.
• W2089885055 hasConcept C519581460 @default.
• W2089885055 hasConcept C529278444 @default.
• W2089885055 hasConcept C55493867 @default.
• W2089885055 hasConcept C86803240 @default.
• W2089885055 hasConceptScore W2089885055C112592302 @default.
• W2089885055 hasConceptScore W2089885055C169760540 @default.
• W2089885055 hasConceptScore W2089885055C170493617 @default.
• W2089885055 hasConceptScore W2089885055C17077164 @default.
• W2089885055 hasConceptScore W2089885055C178790620 @default.
• W2089885055 hasConceptScore W2089885055C185592680 @default.
• W2089885055 hasConceptScore W2089885055C197341189 @default.
• W2089885055 hasConceptScore W2089885055C200170125 @default.
• W2089885055 hasConceptScore W2089885055C2777622882 @default.
• W2089885055 hasConceptScore W2089885055C2779610285 @default.
• W2089885055 hasConceptScore W2089885055C2780775167 @default.
• W2089885055 hasConceptScore W2089885055C2780994212 @default.
• W2089885055 hasConceptScore W2089885055C519581460 @default.
• W2089885055 hasConceptScore W2089885055C529278444 @default.
• W2089885055 hasConceptScore W2089885055C55493867 @default.
• W2089885055 hasConceptScore W2089885055C86803240 @default.
• W2089885055 hasIssue "3-4" @default.
• W2089885055 hasLocation W20898850551 @default.
• W2089885055 hasLocation W20898850552 @default.
• W2089885055 hasOpenAccess W2089885055 @default.
• W2089885055 hasPrimaryLocation W20898850551 @default.
• W2089885055 hasRelatedWork W1972402575 @default.
• W2089885055 hasRelatedWork W1974249396 @default.
• W2089885055 hasRelatedWork W2007715660 @default.
• W2089885055 hasRelatedWork W2038588622 @default.
• W2089885055 hasRelatedWork W2066561110 @default.
• W2089885055 hasRelatedWork W2082329602 @default.
• W2089885055 hasRelatedWork W2090007274 @default.
• W2089885055 hasRelatedWork W2105554432 @default.
• W2089885055 hasRelatedWork W224257749 @default.
• W2089885055 hasRelatedWork W4285127779 @default.
• W2089885055 hasVolume "10" @default.
• W2089885055 isParatext "false" @default.
• W2089885055 isRetracted "false" @default.
• W2089885055 magId "2089885055" @default.
• W2089885055 workType "article" @default.