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- W2089901247 abstract "The bronchodilator effect of a 10 mg/kg dose of theobromine (3,7-dimethylxanthine) was compared with that of 5 mg/kg of theophylline (1,3-dimethylxanthine) in young patients with asthma. Bronchodilation, as assessed by forced vital capacity, forced expiratory volume in the first second, forced expiratory flows at 25%, 50%, and 75% of vital capacity, and percent of forced expiratory volume in the first second/forced vital capacity did not differ significantly between the two drugs. After each drug bronchodilation peaked at 2 hours and lasted for 6 hours, although it was not always statistically significant for theobromine. The mean peak serum concentrations of both drugs, the time at which peak serum concentrations occurred, and elimination half-life values were similar for theobromine and theophylline." @default.
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- W2089901247 date "1985-11-01" @default.
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- W2089901247 title "The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma" @default.
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- W2089901247 doi "https://doi.org/10.1016/0091-6749(85)90674-8" @default.
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