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- W2089901452 abstract "If cells are irradiated late in the mitotic cycle (late G 2 or early prophase), at the following anaphase they frequently exhibit characteristic chromosomal configurations known as sidearm bridges. These are often interpreted as sub-chromatid aberrations and are taken as evidence that chromosomes are multi-stranded. This interpretation, although recently challenged, is supported by experiments based upon the normal replication that converts chromatids to full chromosomes. The rationale is that aberrations involving only one chromatid of a chromosome are converted by replication to chromosome aberrations involving both chromatids. After replication, therefore, there should be no chromatid aberrations remaining unless the initial aberration involved less than a full chromatid. The results show that chromatid aberrations do appear after chromosomal replication: at the second mitosis after irradiation. Another experiment shows that most such chromatid aberrations are not the result of errors in the replication of previous chromatid aberrations." @default.
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- W2089901452 date "1969-12-01" @default.
- W2089901452 modified "2023-09-26" @default.
- W2089901452 title "THE STRANDEDNESS OF CHROMOSOMES: EVIDENCE FROM CHROMOSOMAL ABERRATIONS" @default.
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- W2089901452 doi "https://doi.org/10.1139/g69-092" @default.
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