FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089903375> ?p ?o ?g. }

• W2089903375 endingPage "1087.e3" @default.
• W2089903375 startingPage "1078" @default.
• W2089903375 abstract "Autologous bone marrow mononuclear cell (ABMMNC) therapy has shown promise in patients with heart failure (HF). Cell function analysis may be important in interpreting trial results.In this prospective study, we evaluated the safety and efficacy of the transendocardial delivery of ABMMNCs in no-option patients with chronic HF. Efficacy was assessed by maximal myocardial oxygen consumption, single photon emission computed tomography, 2-dimensional echocardiography, and quality-of-life assessment (Minnesota Living with Heart Failure and Short Form 36). We also characterized patients' bone marrow cells by flow cytometry, colony-forming unit, and proliferative assays.Cell-treated (n = 20) and control patients (n = 10) were similar at baseline. The procedure was safe; adverse events were similar in both groups. Canadian Cardiovascular Society angina score improved significantly (P = .001) in cell-treated patients, but function was not affected. Quality-of-life scores improved significantly at 6 months (P = .009 Minnesota Living with Heart Failure and P = .002 physical component of Short Form 36) over baseline in cell-treated but not control patients. Single photon emission computed tomography data suggested a trend toward improved perfusion in cell-treated patients. The proportion of fixed defects significantly increased in control (P = .02) but not in treated patients (P = .16). Function of patients' bone marrow mononuclear cells was severely impaired. Stratifying cell results by age showed that younger patients (≤60 years) had significantly more mesenchymal progenitor cells (colony-forming unit fibroblasts) than patients >60 years (20.16 ± 14.6 vs 10.92 ± 7.8, P = .04). Furthermore, cell-treated younger patients had significantly improved maximal myocardial oxygen consumption (15 ± 5.8, 18.6 ± 2.7, and 17 ± 3.7 mL/kg per minute at baseline, 3 months, and 6 months, respectively) compared with similarly aged control patients (14.3 ± 2.5, 13.7 ± 3.7, and 14.6 ± 4.7 mL/kg per minute, P = .04).ABMMNC therapy is safe and improves symptoms, quality of life, and possibly perfusion in patients with chronic HF." @default.
• W2089903375 created "2016-06-24" @default.
• W2089903375 creator A5002666676 @default.
• W2089903375 creator A5005733386 @default.
• W2089903375 creator A5010240121 @default.
• W2089903375 creator A5016627330 @default.
• W2089903375 creator A5022531273 @default.
• W2089903375 creator A5025330307 @default.
• W2089903375 creator A5028310711 @default.
• W2089903375 creator A5032470876 @default.
• W2089903375 creator A5034707830 @default.
• W2089903375 creator A5043447056 @default.
• W2089903375 creator A5043769250 @default.
• W2089903375 creator A5045515686 @default.
• W2089903375 creator A5047628018 @default.
• W2089903375 creator A5050635311 @default.
• W2089903375 creator A5054597165 @default.
• W2089903375 creator A5073456407 @default.
• W2089903375 creator A5074968315 @default.
• W2089903375 creator A5083557058 @default.
• W2089903375 creator A5085197899 @default.
• W2089903375 creator A5088979359 @default.
• W2089903375 creator A5090297189 @default.
• W2089903375 date "2011-06-01" @default.
• W2089903375 modified "2023-09-30" @default.
• W2089903375 title "A randomized study of transendocardial injection of autologous bone marrow mononuclear cells and cell function analysis in ischemic heart failure (FOCUS-HF)" @default.
• W2089903375 cites W1787633345 @default.
• W2089903375 cites W1980745034 @default.
• W2089903375 cites W1985954682 @default.
• W2089903375 cites W1994407421 @default.
• W2089903375 cites W1998476642 @default.
• W2089903375 cites W2008379719 @default.
• W2089903375 cites W2009293798 @default.
• W2089903375 cites W2022551413 @default.
• W2089903375 cites W2045456080 @default.
• W2089903375 cites W2046253273 @default.
• W2089903375 cites W2058195291 @default.
• W2089903375 cites W2071746224 @default.
• W2089903375 cites W2086682597 @default.
• W2089903375 cites W2090076255 @default.
• W2089903375 cites W2093608273 @default.
• W2089903375 cites W2094941678 @default.
• W2089903375 cites W2096076325 @default.
• W2089903375 cites W2098892229 @default.
• W2089903375 cites W2102619901 @default.
• W2089903375 cites W2123424761 @default.
• W2089903375 cites W2125235243 @default.
• W2089903375 cites W2132401137 @default.
• W2089903375 cites W2139514988 @default.
• W2089903375 cites W2144139547 @default.
• W2089903375 cites W2156986721 @default.
• W2089903375 cites W2165716414 @default.
• W2089903375 cites W2166539169 @default.
• W2089903375 cites W2413366946 @default.
• W2089903375 cites W1829630473 @default.
• W2089903375 doi "https://doi.org/10.1016/j.ahj.2011.01.028" @default.
• W2089903375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21641354" @default.
• W2089903375 hasPublicationYear "2011" @default.
• W2089903375 type Work @default.
• W2089903375 sameAs 2089903375 @default.
• W2089903375 citedByCount "169" @default.
• W2089903375 countsByYear W20899033752012 @default.
• W2089903375 countsByYear W20899033752013 @default.
• W2089903375 countsByYear W20899033752014 @default.
• W2089903375 countsByYear W20899033752015 @default.
• W2089903375 countsByYear W20899033752016 @default.
• W2089903375 countsByYear W20899033752017 @default.
• W2089903375 countsByYear W20899033752018 @default.
• W2089903375 countsByYear W20899033752019 @default.
• W2089903375 countsByYear W20899033752020 @default.
• W2089903375 countsByYear W20899033752021 @default.
• W2089903375 countsByYear W20899033752022 @default.
• W2089903375 countsByYear W20899033752023 @default.
• W2089903375 crossrefType "journal-article" @default.
• W2089903375 hasAuthorship W2089903375A5002666676 @default.
• W2089903375 hasAuthorship W2089903375A5005733386 @default.
• W2089903375 hasAuthorship W2089903375A5010240121 @default.
• W2089903375 hasAuthorship W2089903375A5016627330 @default.
• W2089903375 hasAuthorship W2089903375A5022531273 @default.
• W2089903375 hasAuthorship W2089903375A5025330307 @default.
• W2089903375 hasAuthorship W2089903375A5028310711 @default.
• W2089903375 hasAuthorship W2089903375A5032470876 @default.
• W2089903375 hasAuthorship W2089903375A5034707830 @default.
• W2089903375 hasAuthorship W2089903375A5043447056 @default.
• W2089903375 hasAuthorship W2089903375A5043769250 @default.
• W2089903375 hasAuthorship W2089903375A5045515686 @default.
• W2089903375 hasAuthorship W2089903375A5047628018 @default.
• W2089903375 hasAuthorship W2089903375A5050635311 @default.
• W2089903375 hasAuthorship W2089903375A5054597165 @default.
• W2089903375 hasAuthorship W2089903375A5073456407 @default.
• W2089903375 hasAuthorship W2089903375A5074968315 @default.
• W2089903375 hasAuthorship W2089903375A5083557058 @default.
• W2089903375 hasAuthorship W2089903375A5085197899 @default.
• W2089903375 hasAuthorship W2089903375A5088979359 @default.
• W2089903375 hasAuthorship W2089903375A5090297189 @default.
• W2089903375 hasConcept C10882517 @default.
• W2089903375 hasConcept C126322002 @default.
• W2089903375 hasConcept C137061746 @default.

• next