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• W2089906696 abstract "Purified CD8+ T cells from influenza A/WSN-immune BALB/c (H-2d) mice respond with the generation of secondary A/WSN-specific Tc cells in vitro when stimulated with a synthetic peptide (NPP) with a sequence derived from influenza A virus nucleoprotein with high affinity for Kd class I MHC molecules. The process of the conversion of NPP-Kd-responding Tc cell precursors into effector Tc cells in a population of CD8+ T cells occurs with no demonstrable requirements for accessory cells or their lymphokine products. The addition of culture supernatants from several mouse and human B cell lymphomas and LPS-activated normal mouse B cells to the culture of NPP-stimulated immune CD8+ T cells enhanced the induction of secondary Ag-specific Tc cells. None of the tested supernatants in the absence of Ag (NPP) induced cytolytic Tc cells, indicating that B cell-derived secretory factors can exert their activity only on Ag-exposed CD8+ T cells. The augmentatory effect of these supernatants on Ag-specific activation of memory CD8+ T cells was attributed to the synergism between B cell-derived factors and IL-2 which is produced endogenously in cultures of NPP-stimulated D8+ T cells. The possible role of B cell-derived helper factors is discussed." @default.
• W2089906696 created "2016-06-24" @default.
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• W2089906696 date "1992-11-01" @default.
• W2089906696 modified "2023-09-26" @default.
• W2089906696 title "Enhancement of Antigen-Specific Activation of CD8+ Memory Cytotoxic T Cells by B Cell-Derived Factors" @default.
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• W2089906696 doi "https://doi.org/10.1016/s0171-2985(11)80394-3" @default.
• W2089906696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1286880" @default.
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