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• W2089910171 abstract "Fibronectin is a principal component of the extracellular matrix. Soluble fibronectin molecules are assembled into the extracellular matrix as insoluble, fibrillar strands via a cell-dependent process. In turn, the interaction of cells with the extracellular matrix form of fibronectin stimulates cell functions critical for tissue repair. Cross-talk between cell-cell and cell-extracellular matrix adhesion complexes is essential for the organization of cells into complex, functional tissue during embryonic development and tissue remodeling. Here, we demonstrate that fibronectin matrix assembly affects the organization, composition, and function of N-cadherin-based adherens junctions. Using fibronectin-null mouse embryonic myofibroblasts, we identified a novel quaternary complex composed of N-cadherin, β-catenin, tensin, and actin that exists in the absence of a fibronectin matrix. In the absence of fibronectin, homophilic N-cadherin ligation recruited both tensin and α5β1 integrins into nascent cell-cell adhesions. Initiation of fibronectin matrix assembly disrupted the association of tensin and actin with N-cadherin, released α5β1 integrins and tensin from cell-cell contacts, stimulated N-cadherin reorganization into thin cellular protrusions, and decreased N-cadherin adhesion. Fibronectin matrix assembly has been shown to recruit α5β1 integrins and tensin into fibrillar adhesions. Taken together, these studies suggest that tensin serves as a common cytoskeletal link for integrin- and cadherin-based adhesions and that the translocation of α5β1 integrins from cell-cell contacts into fibrillar adhesions during fibronectin matrix assembly is a novel mechanism by which cell-cell and cell-matrix adhesions are coordinated." @default.
• W2089910171 created "2016-06-24" @default.
• W2089910171 creator A5005773579 @default.
• W2089910171 creator A5014936239 @default.
• W2089910171 creator A5040554687 @default.
• W2089910171 date "2011-01-01" @default.
• W2089910171 modified "2023-10-01" @default.
• W2089910171 title "N-cadherin Cell-Cell Adhesion Complexes Are Regulated by Fibronectin Matrix Assembly" @default.
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• W2089910171 doi "https://doi.org/10.1074/jbc.m110.115733" @default.
• W2089910171 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3024807" @default.
• W2089910171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21084302" @default.
• W2089910171 hasPublicationYear "2011" @default.
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