SemOpenAlex |

SemOpenAlex

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089918853> ?p ?o ?g. }

Showing items 1 to 100 of ±142 with 100 items per page.

W2089918853 endingPage "2493" @default.
W2089918853 startingPage "2484" @default.
W2089918853 abstract "Circulating monocytes can differentiate into dendritic cells (moDCs), which are potent inducers of adaptive immune responses. Previous reports show that granulocyte macrophage–colony-stimulating factor (GM-CSF) and interleukin-4 induce monocyte differentiation into moDCs in vitro, but little is known about the physiological requirements that initiate moDC differentiation in vivo. Here we show that a unique natural killer (NK) cell subset (CD3−CD56bright) that accumulates in lymph nodes and chronically inflamed tissues triggers CD14+ monocytes to differentiate into potent T-helper-1 (TH1) promoting DC. This process requires direct contact of monocytes with NK cells and is mediated by GM-CSF and CD154 derived from NK cells. It is noteworthy that synovial fluid (SF) from patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA), but not osteoarthritis (OA), induces monocytes to differentiate into DC. However, this process occurs only in the presence of NK cells. We propose that NK cells play a role in the maintenance of TH1-mediated inflammatory diseases such as RA by providing a local milieu for monocytes to differentiate into DC." @default.
W2089918853 created "2016-06-24" @default.
W2089918853 creator A5000229478 @default.
W2089918853 creator A5000823009 @default.
W2089918853 creator A5015342326 @default.
W2089918853 creator A5034001543 @default.
W2089918853 creator A5065351158 @default.
W2089918853 creator A5067124668 @default.
W2089918853 creator A5076121246 @default.
W2089918853 creator A5082575419 @default.
W2089918853 creator A5087775930 @default.
W2089918853 date "2007-10-01" @default.
W2089918853 modified "2023-10-02" @default.
W2089918853 title "Natural killer cells trigger differentiation of monocytes into dendritic cells" @default.
W2089918853 cites W1515490504 @default.
W2089918853 cites W1646818583 @default.
W2089918853 cites W1661544713 @default.
W2089918853 cites W1735223593 @default.
W2089918853 cites W1790397959 @default.
W2089918853 cites W1976833987 @default.
W2089918853 cites W1977797737 @default.
W2089918853 cites W1991188836 @default.
W2089918853 cites W2006073656 @default.
W2089918853 cites W2007400263 @default.
W2089918853 cites W2013716230 @default.
W2089918853 cites W2017072222 @default.
W2089918853 cites W2020313517 @default.
W2089918853 cites W2021377837 @default.
W2089918853 cites W2028092080 @default.
W2089918853 cites W2028359609 @default.
W2089918853 cites W2028593992 @default.
W2089918853 cites W2034551415 @default.
W2089918853 cites W2036264638 @default.
W2089918853 cites W2040564804 @default.
W2089918853 cites W2042113030 @default.
W2089918853 cites W2047102094 @default.
W2089918853 cites W2059467769 @default.
W2089918853 cites W2060005821 @default.
W2089918853 cites W2065779257 @default.
W2089918853 cites W2072818859 @default.
W2089918853 cites W2075195548 @default.
W2089918853 cites W2081670280 @default.
W2089918853 cites W2083512095 @default.
W2089918853 cites W2086172243 @default.
W2089918853 cites W2088024377 @default.
W2089918853 cites W2108560097 @default.
W2089918853 cites W2109044040 @default.
W2089918853 cites W2109314033 @default.
W2089918853 cites W2112744121 @default.
W2089918853 cites W2113403004 @default.
W2089918853 cites W2113779347 @default.
W2089918853 cites W2122789445 @default.
W2089918853 cites W2125739592 @default.
W2089918853 cites W2131761283 @default.
W2089918853 cites W2134254929 @default.
W2089918853 cites W2135597173 @default.
W2089918853 cites W2140944306 @default.
W2089918853 cites W2148343285 @default.
W2089918853 cites W2152598721 @default.
W2089918853 cites W2157569416 @default.
W2089918853 cites W2159732692 @default.
W2089918853 cites W2162620875 @default.
W2089918853 cites W2165020893 @default.
W2089918853 cites W2165323521 @default.
W2089918853 cites W2165920713 @default.
W2089918853 cites W2171709048 @default.
W2089918853 doi "https://doi.org/10.1182/blood-2007-02-076364" @default.
W2089918853 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1988958" @default.
W2089918853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17626840" @default.
W2089918853 hasPublicationYear "2007" @default.
W2089918853 type Work @default.
W2089918853 sameAs 2089918853 @default.
W2089918853 citedByCount "100" @default.
W2089918853 countsByYear W20899188532012 @default.
W2089918853 countsByYear W20899188532013 @default.
W2089918853 countsByYear W20899188532014 @default.
W2089918853 countsByYear W20899188532015 @default.
W2089918853 countsByYear W20899188532017 @default.
W2089918853 countsByYear W20899188532018 @default.
W2089918853 countsByYear W20899188532019 @default.
W2089918853 countsByYear W20899188532020 @default.
W2089918853 countsByYear W20899188532021 @default.
W2089918853 countsByYear W20899188532022 @default.
W2089918853 countsByYear W20899188532023 @default.
W2089918853 crossrefType "journal-article" @default.
W2089918853 hasAuthorship W2089918853A5000229478 @default.
W2089918853 hasAuthorship W2089918853A5000823009 @default.
W2089918853 hasAuthorship W2089918853A5015342326 @default.
W2089918853 hasAuthorship W2089918853A5034001543 @default.
W2089918853 hasAuthorship W2089918853A5065351158 @default.
W2089918853 hasAuthorship W2089918853A5067124668 @default.
W2089918853 hasAuthorship W2089918853A5076121246 @default.
W2089918853 hasAuthorship W2089918853A5082575419 @default.
W2089918853 hasAuthorship W2089918853A5087775930 @default.
W2089918853 hasBestOaLocation W20899188531 @default.
W2089918853 hasConcept C149532602 @default.
W2089918853 hasConcept C154317977 @default.
W2089918853 hasConcept C202751555 @default.