FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089920392> ?p ?o ?g. }

• W2089920392 endingPage "91" @default.
• W2089920392 startingPage "81" @default.
• W2089920392 abstract "The capability of granulosa and theca interna cells, from preovulatory follicles of the domestic hen, to metabolize steroid precursors was evaluated. Granulosa and theca interna cells were isolated from ovarian preovulatory follicles at three different developmental stages: F1, F3 and F5. Tritiated pregnenolone (P5), progesterone (P4), dehydroepiandrosterone (DHEA), androstenedione (A4) and testosterone (T) were employed as precursors and their metabolic products were evaluated. The major metabolite of P5 by granulosa cells was P4, but we also observed low amounts of 5β-pregnandione. DHEA metabolism by granulosa cells yielded mainly A4, and minute quantities of 5β-androstan-3,17-dione (5β-dione) were detected. The only significant metabolite obtained in granulosa cells from A4 was 5β-dione, whereas T was only transformed into A4. On the other hand, P5 metabolism by theca interna cells yielded A4 as the main product, also P4, 17α-OHP4, 17α-OHP5, 5β-pregnandione, and DHEA, were found. When DHEA was the precursor A4 was produced in higher amounts than 5β-dione. A4 was mainly transformed into 5β-dione. In similar conditions, T was transformed into A4. These results show that granulosa cells have enzymatic activities of 3β-hydroxysteroid dehydrogenase/5-4 isomerase (3β-HSD from P5 and DHEA), 17β-hydroxysteroid dehydrogenase (17β-HSD from T) and 5β-reductase (from P5, DHEA and A4). Whereas theca interna cells have enzymatic activities of cytochrome P450c17 (from P5 and P4), 3β-HSD (from P5 and DHEA), 17β-HSD (from T) and 5β-reductase (from P4, DHEA and A4). These data support the concept that theca interna cells have the ability to synthesize androgens from progestins produced in granulosa cells. In addition, since theca interna cells did not show the capacity to aromatize androgens suggests that interaction between theca interna and theca externa cells occurs in vivo, thus confirming the three cell model for estrogen production. Furthermore, the fact that other metabolites were produced both in granulosa and theca interna cells, but in a different extent, suggests that complex mechanisms are participating in the regulation of steroid synthesis in avian ovary follicles." @default.
• W2089920392 created "2016-06-24" @default.
• W2089920392 creator A5041837630 @default.
• W2089920392 creator A5043659439 @default.
• W2089920392 creator A5046116966 @default.
• W2089920392 creator A5065223978 @default.
• W2089920392 date "1998-06-01" @default.
• W2089920392 modified "2023-10-03" @default.
• W2089920392 title "Steroid metabolism in granulosa and theca interna cells from preovulatory follicles of domestic hen (Gallus domesticus)" @default.
• W2089920392 cites W1971579055 @default.
• W2089920392 cites W1974093694 @default.
• W2089920392 cites W1979635470 @default.
• W2089920392 cites W1979708676 @default.
• W2089920392 cites W1981793184 @default.
• W2089920392 cites W1983928050 @default.
• W2089920392 cites W1986475509 @default.
• W2089920392 cites W2010769805 @default.
• W2089920392 cites W2011939123 @default.
• W2089920392 cites W2013985800 @default.
• W2089920392 cites W2020387392 @default.
• W2089920392 cites W2020803551 @default.
• W2089920392 cites W2020880417 @default.
• W2089920392 cites W2026397121 @default.
• W2089920392 cites W2026877749 @default.
• W2089920392 cites W2027587001 @default.
• W2089920392 cites W2035653925 @default.
• W2089920392 cites W2035861720 @default.
• W2089920392 cites W2044106412 @default.
• W2089920392 cites W2047301019 @default.
• W2089920392 cites W2048156664 @default.
• W2089920392 cites W2062820421 @default.
• W2089920392 cites W2074488841 @default.
• W2089920392 cites W2093162622 @default.
• W2089920392 cites W2093387619 @default.
• W2089920392 cites W2109347638 @default.
• W2089920392 cites W2123102042 @default.
• W2089920392 cites W2126458342 @default.
• W2089920392 cites W635882015 @default.
• W2089920392 doi "https://doi.org/10.1016/s0378-4320(98)00087-6" @default.
• W2089920392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9728817" @default.
• W2089920392 hasPublicationYear "1998" @default.
• W2089920392 type Work @default.
• W2089920392 sameAs 2089920392 @default.
• W2089920392 citedByCount "36" @default.
• W2089920392 countsByYear W20899203922012 @default.
• W2089920392 countsByYear W20899203922014 @default.
• W2089920392 countsByYear W20899203922015 @default.
• W2089920392 countsByYear W20899203922017 @default.
• W2089920392 countsByYear W20899203922019 @default.
• W2089920392 countsByYear W20899203922020 @default.
• W2089920392 countsByYear W20899203922022 @default.
• W2089920392 crossrefType "journal-article" @default.
• W2089920392 hasAuthorship W2089920392A5041837630 @default.
• W2089920392 hasAuthorship W2089920392A5043659439 @default.
• W2089920392 hasAuthorship W2089920392A5046116966 @default.
• W2089920392 hasAuthorship W2089920392A5065223978 @default.
• W2089920392 hasConcept C126322002 @default.
• W2089920392 hasConcept C134018914 @default.
• W2089920392 hasConcept C175805485 @default.
• W2089920392 hasConcept C181199279 @default.
• W2089920392 hasConcept C185592680 @default.
• W2089920392 hasConcept C2776317432 @default.
• W2089920392 hasConcept C2776683971 @default.
• W2089920392 hasConcept C2776986892 @default.
• W2089920392 hasConcept C2776992908 @default.
• W2089920392 hasConcept C2777477808 @default.
• W2089920392 hasConcept C2777911890 @default.
• W2089920392 hasConcept C2778324911 @default.
• W2089920392 hasConcept C2780193516 @default.
• W2089920392 hasConcept C2780902042 @default.
• W2089920392 hasConcept C55493867 @default.
• W2089920392 hasConcept C71315377 @default.
• W2089920392 hasConcept C71924100 @default.
• W2089920392 hasConcept C86803240 @default.
• W2089920392 hasConceptScore W2089920392C126322002 @default.
• W2089920392 hasConceptScore W2089920392C134018914 @default.
• W2089920392 hasConceptScore W2089920392C175805485 @default.
• W2089920392 hasConceptScore W2089920392C181199279 @default.
• W2089920392 hasConceptScore W2089920392C185592680 @default.
• W2089920392 hasConceptScore W2089920392C2776317432 @default.
• W2089920392 hasConceptScore W2089920392C2776683971 @default.
• W2089920392 hasConceptScore W2089920392C2776986892 @default.
• W2089920392 hasConceptScore W2089920392C2776992908 @default.
• W2089920392 hasConceptScore W2089920392C2777477808 @default.
• W2089920392 hasConceptScore W2089920392C2777911890 @default.
• W2089920392 hasConceptScore W2089920392C2778324911 @default.
• W2089920392 hasConceptScore W2089920392C2780193516 @default.
• W2089920392 hasConceptScore W2089920392C2780902042 @default.
• W2089920392 hasConceptScore W2089920392C55493867 @default.
• W2089920392 hasConceptScore W2089920392C71315377 @default.
• W2089920392 hasConceptScore W2089920392C71924100 @default.
• W2089920392 hasConceptScore W2089920392C86803240 @default.
• W2089920392 hasIssue "1" @default.
• W2089920392 hasLocation W20899203921 @default.
• W2089920392 hasLocation W20899203922 @default.
• W2089920392 hasOpenAccess W2089920392 @default.
• W2089920392 hasPrimaryLocation W20899203921 @default.
• W2089920392 hasRelatedWork W2005723451 @default.

• next