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- W2089922967 abstract "Since the introduction of digitalis into medicine by Withering1in 1785, medical practitioners have regulated the administration of digitalis according to the signs of clinical improvement or the appearance of toxic effects. To avoid exposing the patient to the discomfort of toxic effects on the one hand, or to insufficient medication on the other, knowledge of the daily maintenance dose (which is to be considered the same as the amount of digitalis effect that disappears from the body each day) is most essential. The rate of disappearance of the digitalis bodies from the body was studied clinically by Pardee2in 1919. Tincture of digitalis was given until certain mild toxic symptoms were apparent and then the drug was omitted for a number of days. The tincture was again administered until the same toxic signs reappeared. The amount given in the second course, divided by the number of days" @default.
- W2089922967 created "2016-06-24" @default.
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- W2089922967 date "1929-01-19" @default.
- W2089922967 modified "2023-09-25" @default.
- W2089922967 title "THE MAINTENANCE DOSE OF DIGITALIS: AN ELECTROCARDIOGRAPHIC STUDY" @default.
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- W2089922967 doi "https://doi.org/10.1001/jama.1929.02700290014004" @default.
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