FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089925679> ?p ?o ?g. }

• W2089925679 endingPage "225" @default.
• W2089925679 startingPage "219" @default.
• W2089925679 abstract "Sarco(endo)plasmic reticulum calcium ATPases (SERCA) are cellular pumps that transport Ca(2+) into the sarcoplasmic reticulum (SR). Serca2 is the most widely expressed gene family member. The very early embryonic lethality of Serca2(null) mouse embryos has precluded further evaluation of loss of Serca2 function in the context of organ physiology. We have generated mice carrying a conditional Serca2(flox) allele which allows disruption of the Serca2 gene in an organ-specific and/or inducible manner. The model was tested by mating Serca2(flox) mice with MLC-2v(wt/Cre) mice and with alphaMHC-Cre transgenic mice. In heterozygous Serca2(wt/flox)MLC-2v(wt/Cre) mice, the expression of SERCA2a and SERCA2b proteins were reduced in the heart and slow skeletal muscle, in accordance with the expression pattern of the MLC-2v gene. In Serca2(flox/flox) Tg(alphaMHC-Cre) embryos with early homozygous cardiac Serca2 disruption, normal embryonic development and yolk sac circulation was maintained up to at least embryonic stage E10.5. The Serca2(flox) mouse is the first murine conditional gene disruption model for the SERCA family of Ca(2+) ATPases, and should be a powerful tool for investigating specific physiological roles of SERCA2 function in a range of tissues and organs in vivo both in adult and embryonic stages." @default.
• W2089925679 created "2016-06-24" @default.
• W2089925679 creator A5000410056 @default.
• W2089925679 creator A5007318753 @default.
• W2089925679 creator A5020789496 @default.
• W2089925679 creator A5026631133 @default.
• W2089925679 creator A5032822233 @default.
• W2089925679 creator A5036204802 @default.
• W2089925679 creator A5052570174 @default.
• W2089925679 creator A5054391201 @default.
• W2089925679 creator A5072502003 @default.
• W2089925679 creator A5077784325 @default.
• W2089925679 creator A5079513384 @default.
• W2089925679 creator A5085935898 @default.
• W2089925679 date "2009-09-01" @default.
• W2089925679 modified "2023-09-27" @default.
• W2089925679 title "Mice carrying a conditional Serca2flox allele for the generation of Ca2+ handling-deficient mouse models" @default.
• W2089925679 cites W1970093299 @default.
• W2089925679 cites W1977353525 @default.
• W2089925679 cites W1979512764 @default.
• W2089925679 cites W1994241975 @default.
• W2089925679 cites W1995128325 @default.
• W2089925679 cites W1997018082 @default.
• W2089925679 cites W2007555121 @default.
• W2089925679 cites W2013624095 @default.
• W2089925679 cites W2016668488 @default.
• W2089925679 cites W2018800923 @default.
• W2089925679 cites W2029031792 @default.
• W2089925679 cites W2030016364 @default.
• W2089925679 cites W2036351079 @default.
• W2089925679 cites W2037521168 @default.
• W2089925679 cites W2041903850 @default.
• W2089925679 cites W2046226087 @default.
• W2089925679 cites W2048732846 @default.
• W2089925679 cites W2051986618 @default.
• W2089925679 cites W2052876150 @default.
• W2089925679 cites W2062494181 @default.
• W2089925679 cites W2071568942 @default.
• W2089925679 cites W2073835693 @default.
• W2089925679 cites W2079697827 @default.
• W2089925679 cites W2087479677 @default.
• W2089925679 cites W2106540045 @default.
• W2089925679 cites W2111416247 @default.
• W2089925679 cites W2115095194 @default.
• W2089925679 cites W2119326707 @default.
• W2089925679 cites W2122403406 @default.
• W2089925679 cites W2137007955 @default.
• W2089925679 cites W2146753647 @default.
• W2089925679 cites W2152711806 @default.
• W2089925679 cites W2160306365 @default.
• W2089925679 cites W2160365682 @default.
• W2089925679 cites W2161549748 @default.
• W2089925679 cites W2170320462 @default.
• W2089925679 cites W2213808425 @default.
• W2089925679 doi "https://doi.org/10.1016/j.ceca.2009.07.004" @default.
• W2089925679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4313567" @default.
• W2089925679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19692123" @default.
• W2089925679 hasPublicationYear "2009" @default.
• W2089925679 type Work @default.
• W2089925679 sameAs 2089925679 @default.
• W2089925679 citedByCount "28" @default.
• W2089925679 countsByYear W20899256792012 @default.
• W2089925679 countsByYear W20899256792013 @default.
• W2089925679 countsByYear W20899256792014 @default.
• W2089925679 countsByYear W20899256792015 @default.
• W2089925679 countsByYear W20899256792018 @default.
• W2089925679 countsByYear W20899256792019 @default.
• W2089925679 countsByYear W20899256792021 @default.
• W2089925679 countsByYear W20899256792022 @default.
• W2089925679 countsByYear W20899256792023 @default.
• W2089925679 crossrefType "journal-article" @default.
• W2089925679 hasAuthorship W2089925679A5000410056 @default.
• W2089925679 hasAuthorship W2089925679A5007318753 @default.
• W2089925679 hasAuthorship W2089925679A5020789496 @default.
• W2089925679 hasAuthorship W2089925679A5026631133 @default.
• W2089925679 hasAuthorship W2089925679A5032822233 @default.
• W2089925679 hasAuthorship W2089925679A5036204802 @default.
• W2089925679 hasAuthorship W2089925679A5052570174 @default.
• W2089925679 hasAuthorship W2089925679A5054391201 @default.
• W2089925679 hasAuthorship W2089925679A5072502003 @default.
• W2089925679 hasAuthorship W2089925679A5077784325 @default.
• W2089925679 hasAuthorship W2089925679A5079513384 @default.
• W2089925679 hasAuthorship W2089925679A5085935898 @default.
• W2089925679 hasBestOaLocation W20899256792 @default.
• W2089925679 hasConcept C102230213 @default.
• W2089925679 hasConcept C104317684 @default.
• W2089925679 hasConcept C111829913 @default.
• W2089925679 hasConcept C122229402 @default.
• W2089925679 hasConcept C126322002 @default.
• W2089925679 hasConcept C127716648 @default.
• W2089925679 hasConcept C134018914 @default.
• W2089925679 hasConcept C141035611 @default.
• W2089925679 hasConcept C145103041 @default.
• W2089925679 hasConcept C151730666 @default.
• W2089925679 hasConcept C158617107 @default.
• W2089925679 hasConcept C164659718 @default.
• W2089925679 hasConcept C181199279 @default.
• W2089925679 hasConcept C196843134 @default.

• next