FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089928516> ?p ?o ?g. }

• W2089928516 endingPage "1230" @default.
• W2089928516 startingPage "1220" @default.
• W2089928516 abstract "Even though altered metabolism representing a hallmark of cancer was proposed nearly a century ago, recent technological advances have allowed investigators to continue uncovering a previously unrecognized complexity of metabolic programs that drive tumorigenesis beyond that of aerobic glycolysis. The bioenergetic state of a diverse panel of glioblastoma models, including isogenic lines derived from a genetically engineered adult astrocytic mouse model and patient-derived glioblastoma stem cells, was determined at baseline and in stressed conditions. Mechanisms contributing to the discovered metabolic phenotypes were determined through molecular and chemical perturbation, and their biological consequences were evaluated in vivo and in patient samples. Attenuated mitochondrial reserve capacity was identified as a common metabolic phenotype in glioblastoma lines. This phenotype was linked mechanistically with the capacity of Ras-mediated signaling to inhibit pyruvate dehydrogenase (PDH) activity through downregulation of PDH phosphatase (PDP) expression. PDP1 repression was validated clinically in patient-derived samples, suggesting that aberrant cellular signaling typical of glioblastoma actively modulates PDH activity. This phenotype was reversed through both chemical and molecular perturbation. Restoration of PDH activity through stable expression of PDP1-impaired tumorigenic potential. These findings support the central role that PDH regulation plays as a downstream consequence of aberrant signaling associated with gliomagenesis and the scientific rationale to continue to develop and test clinical strategies designed to activate PDH as a form of anticancer therapy in glioblastoma." @default.
• W2089928516 created "2016-06-24" @default.
• W2089928516 creator A5012125713 @default.
• W2089928516 creator A5020843285 @default.
• W2089928516 creator A5031142519 @default.
• W2089928516 creator A5037386621 @default.
• W2089928516 creator A5040533368 @default.
• W2089928516 creator A5049196662 @default.
• W2089928516 creator A5088103390 @default.
• W2089928516 date "2015-02-23" @default.
• W2089928516 modified "2023-10-17" @default.
• W2089928516 title "Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis" @default.
• W2089928516 cites W1751530372 @default.
• W2089928516 cites W1982647833 @default.
• W2089928516 cites W1984855371 @default.
• W2089928516 cites W1986967524 @default.
• W2089928516 cites W1997099893 @default.
• W2089928516 cites W2006883359 @default.
• W2089928516 cites W2007145550 @default.
• W2089928516 cites W2018641577 @default.
• W2089928516 cites W2022461902 @default.
• W2089928516 cites W2022899908 @default.
• W2089928516 cites W2025183726 @default.
• W2089928516 cites W2028897202 @default.
• W2089928516 cites W2039243233 @default.
• W2089928516 cites W2039603291 @default.
• W2089928516 cites W2044085368 @default.
• W2089928516 cites W2044624356 @default.
• W2089928516 cites W2047470479 @default.
• W2089928516 cites W2054115441 @default.
• W2089928516 cites W2069269337 @default.
• W2089928516 cites W2080719056 @default.
• W2089928516 cites W2081758137 @default.
• W2089928516 cites W2096287682 @default.
• W2089928516 cites W2100723895 @default.
• W2089928516 cites W2111762809 @default.
• W2089928516 cites W2116876842 @default.
• W2089928516 cites W2125096000 @default.
• W2089928516 cites W2126524529 @default.
• W2089928516 cites W2128469603 @default.
• W2089928516 cites W2135404870 @default.
• W2089928516 cites W2151980465 @default.
• W2089928516 cites W2154848784 @default.
• W2089928516 cites W2161128788 @default.
• W2089928516 cites W2164524616 @default.
• W2089928516 cites W2322386893 @default.
• W2089928516 cites W4243903519 @default.
• W2089928516 doi "https://doi.org/10.1093/neuonc/nou369" @default.
• W2089928516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4588752" @default.
• W2089928516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25712957" @default.
• W2089928516 hasPublicationYear "2015" @default.
• W2089928516 type Work @default.
• W2089928516 sameAs 2089928516 @default.
• W2089928516 citedByCount "29" @default.
• W2089928516 countsByYear W20899285162015 @default.
• W2089928516 countsByYear W20899285162016 @default.
• W2089928516 countsByYear W20899285162017 @default.
• W2089928516 countsByYear W20899285162018 @default.
• W2089928516 countsByYear W20899285162019 @default.
• W2089928516 countsByYear W20899285162020 @default.
• W2089928516 countsByYear W20899285162021 @default.
• W2089928516 countsByYear W20899285162022 @default.
• W2089928516 countsByYear W20899285162023 @default.
• W2089928516 crossrefType "journal-article" @default.
• W2089928516 hasAuthorship W2089928516A5012125713 @default.
• W2089928516 hasAuthorship W2089928516A5020843285 @default.
• W2089928516 hasAuthorship W2089928516A5031142519 @default.
• W2089928516 hasAuthorship W2089928516A5037386621 @default.
• W2089928516 hasAuthorship W2089928516A5040533368 @default.
• W2089928516 hasAuthorship W2089928516A5049196662 @default.
• W2089928516 hasAuthorship W2089928516A5088103390 @default.
• W2089928516 hasBestOaLocation W20899285162 @default.
• W2089928516 hasConcept C100206155 @default.
• W2089928516 hasConcept C104317684 @default.
• W2089928516 hasConcept C121608353 @default.
• W2089928516 hasConcept C127561419 @default.
• W2089928516 hasConcept C127716648 @default.
• W2089928516 hasConcept C181199279 @default.
• W2089928516 hasConcept C20251656 @default.
• W2089928516 hasConcept C28859421 @default.
• W2089928516 hasConcept C502942594 @default.
• W2089928516 hasConcept C54355233 @default.
• W2089928516 hasConcept C55493867 @default.
• W2089928516 hasConcept C555283112 @default.
• W2089928516 hasConcept C55885012 @default.
• W2089928516 hasConcept C62231903 @default.
• W2089928516 hasConcept C62478195 @default.
• W2089928516 hasConcept C86803240 @default.
• W2089928516 hasConcept C88099638 @default.
• W2089928516 hasConcept C95444343 @default.
• W2089928516 hasConceptScore W2089928516C100206155 @default.
• W2089928516 hasConceptScore W2089928516C104317684 @default.
• W2089928516 hasConceptScore W2089928516C121608353 @default.
• W2089928516 hasConceptScore W2089928516C127561419 @default.
• W2089928516 hasConceptScore W2089928516C127716648 @default.
• W2089928516 hasConceptScore W2089928516C181199279 @default.
• W2089928516 hasConceptScore W2089928516C20251656 @default.
• W2089928516 hasConceptScore W2089928516C28859421 @default.

• next