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• W2089939599 abstract "Diabetic nephropathy is the leading cause of end-stage renal disease in humans in the Western world. The recent development of Na + -glucose cotransporter 2 (SGLT2) inhibitors offers a new antidiabetic therapy via enhanced glucose excretion. Whether this strategy exerts beneficial effects on the development of type 2 diabetic nephropathy is still largely unclear. We investigated the effects of the specific SGLT2 inhibitor empagliflozin in BTBR.Cg-Lep<ob>/WiscJ (BTBR ob/ ob) mice, which spontaneously develop type 2 diabetic nephropathy. In the first experiment, BTBR ob/ ob mice received either a diet containing 300 ppm empagliflozin or equicaloric placebo chow for 12 wk. In the second experiment, BTBR ob/ ob mice received 1 μg·kg body wt −1 ·day −1 ANG II to induce arterial hypertension and were separated into the same two diet groups for 6 wk. In both experiments, empagliflozin treatment enhanced glucosuria, thereby lowering blood glucose. Independently of hypertension, empagliflozin reduced albuminuria in diabetic mice. However, empagliflozin treatment affected diabetes-related glomerular hypertrophy, markers of renal inflammation, and mesangial matrix expansion only in BTBR ob/ ob mice without hypertension. In summary, empagliflozin demonstrated significant antihyperglycemic effects, differentially ameliorating early features of diabetic nephropathy in BTBR ob/ ob mice with and without hypertension." @default.
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• W2089939599 date "2014-08-01" @default.
• W2089939599 modified "2023-09-24" @default.
• W2089939599 title "The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR <i>ob</i>/<i>ob</i> type 2 diabetic mice with and without hypertension" @default.
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• W2089939599 doi "https://doi.org/10.1152/ajprenal.00145.2014" @default.
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