FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089940930> ?p ?o ?g. }

• W2089940930 endingPage "5620" @default.
• W2089940930 startingPage "5613" @default.
• W2089940930 abstract "The objective of this study was to elucidate the influence of disease severity, deiodination, sulfation, thyroid hormone binding, and dopamine use on thyroid function in euthyroid sick syndrome.The study was performed at a university-affiliated pediatric intensive care unit (PICU).This was an observational cohort study.Sixty-nine children with meningococcal sepsis were studied.Differences in thyroid function among nonsurvivors, shock survivors, and sepsis survivors on PICU admission were the main outcome measures.The main study group consisted of 45 non-dopamine-treated children. All children had decreased total T3 (TT3)/rT3 ratios without elevated TSH. T4 sulfate levels were decreased in 88%. Nonsurvivors had paradoxically higher TT3/rT3 ratios than shock survivors (0.71 vs. 0.30); this ratio also correlated with shorter duration of disease (r = -0.43). TT4 and T4-binding globulin (TBG) levels declined with increasing disease severity. TBG levels correlated inversely with elastase levels (r = -0.46). Only TSH levels were significantly lower in 24 dopamine-treated children compared with non-dopamine-treated children (0.65 vs. 0.84), whereas other thyroid hormones did not significantly differ. Both higher TT3/rT3 ratios and lower TT4 levels were predictive for mortality, but this disappeared when IL-6 was entered into the regression model.All children with meningococcal sepsis showed signs of euthyroid sick syndrome. Alterations in peripheral thyroid hormone metabolism related inversely to the duration of disease and seemed to be enacted by profound induction of type 3 deiodinase rather than by down-regulation of type 1. Lower TT4 levels were related to increased turnover of TBG by elastase. Dopamine was found to suppress only TSH secretion, not other thyroid hormone levels, on PICU admission. Both the TT3/rT3 ratio and TT4 levels were predictive for mortality, but were not superior to IL-6." @default.
• W2089940930 created "2016-06-24" @default.
• W2089940930 creator A5012141421 @default.
• W2089940930 creator A5018145087 @default.
• W2089940930 creator A5028109035 @default.
• W2089940930 creator A5038154014 @default.
• W2089940930 creator A5042172716 @default.
• W2089940930 creator A5047355338 @default.
• W2089940930 creator A5081457322 @default.
• W2089940930 creator A5088038178 @default.
• W2089940930 date "2005-10-01" @default.
• W2089940930 modified "2023-09-26" @default.
• W2089940930 title "Euthyroid Sick Syndrome in Meningococcal Sepsis: The Impact of Peripheral Thyroid Hormone Metabolism and Binding Proteins" @default.
• W2089940930 cites W1898928487 @default.
• W2089940930 cites W1967981321 @default.
• W2089940930 cites W1973477505 @default.
• W2089940930 cites W1991648262 @default.
• W2089940930 cites W1994869560 @default.
• W2089940930 cites W1998437047 @default.
• W2089940930 cites W2001159361 @default.
• W2089940930 cites W2004533465 @default.
• W2089940930 cites W2005891136 @default.
• W2089940930 cites W2008122954 @default.
• W2089940930 cites W2013303961 @default.
• W2089940930 cites W2013490776 @default.
• W2089940930 cites W2017041530 @default.
• W2089940930 cites W2017473387 @default.
• W2089940930 cites W2020610635 @default.
• W2089940930 cites W2027251848 @default.
• W2089940930 cites W2030749664 @default.
• W2089940930 cites W2035197371 @default.
• W2089940930 cites W2050262822 @default.
• W2089940930 cites W2069329913 @default.
• W2089940930 cites W2078560780 @default.
• W2089940930 cites W2082560998 @default.
• W2089940930 cites W2090110948 @default.
• W2089940930 cites W2104878795 @default.
• W2089940930 cites W2105220294 @default.
• W2089940930 cites W2106664880 @default.
• W2089940930 cites W2108904735 @default.
• W2089940930 cites W2118994157 @default.
• W2089940930 cites W2121588417 @default.
• W2089940930 cites W2135981692 @default.
• W2089940930 cites W2156563642 @default.
• W2089940930 cites W2160599609 @default.
• W2089940930 cites W2165821124 @default.
• W2089940930 cites W2166035250 @default.
• W2089940930 cites W2172044996 @default.
• W2089940930 cites W2405756312 @default.
• W2089940930 cites W2409152932 @default.
• W2089940930 doi "https://doi.org/10.1210/jc.2005-0888" @default.
• W2089940930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16076941" @default.
• W2089940930 hasPublicationYear "2005" @default.
• W2089940930 type Work @default.
• W2089940930 sameAs 2089940930 @default.
• W2089940930 citedByCount "76" @default.
• W2089940930 countsByYear W20899409302012 @default.
• W2089940930 countsByYear W20899409302013 @default.
• W2089940930 countsByYear W20899409302014 @default.
• W2089940930 countsByYear W20899409302015 @default.
• W2089940930 countsByYear W20899409302016 @default.
• W2089940930 countsByYear W20899409302017 @default.
• W2089940930 countsByYear W20899409302018 @default.
• W2089940930 countsByYear W20899409302019 @default.
• W2089940930 countsByYear W20899409302021 @default.
• W2089940930 countsByYear W20899409302022 @default.
• W2089940930 countsByYear W20899409302023 @default.
• W2089940930 crossrefType "journal-article" @default.
• W2089940930 hasAuthorship W2089940930A5012141421 @default.
• W2089940930 hasAuthorship W2089940930A5018145087 @default.
• W2089940930 hasAuthorship W2089940930A5028109035 @default.
• W2089940930 hasAuthorship W2089940930A5038154014 @default.
• W2089940930 hasAuthorship W2089940930A5042172716 @default.
• W2089940930 hasAuthorship W2089940930A5047355338 @default.
• W2089940930 hasAuthorship W2089940930A5081457322 @default.
• W2089940930 hasAuthorship W2089940930A5088038178 @default.
• W2089940930 hasConcept C126322002 @default.
• W2089940930 hasConcept C134018914 @default.
• W2089940930 hasConcept C2777195454 @default.
• W2089940930 hasConcept C2777316304 @default.
• W2089940930 hasConcept C2778384902 @default.
• W2089940930 hasConcept C2778840127 @default.
• W2089940930 hasConcept C2993291352 @default.
• W2089940930 hasConcept C526584372 @default.
• W2089940930 hasConcept C71315377 @default.
• W2089940930 hasConcept C71924100 @default.
• W2089940930 hasConceptScore W2089940930C126322002 @default.
• W2089940930 hasConceptScore W2089940930C134018914 @default.
• W2089940930 hasConceptScore W2089940930C2777195454 @default.
• W2089940930 hasConceptScore W2089940930C2777316304 @default.
• W2089940930 hasConceptScore W2089940930C2778384902 @default.
• W2089940930 hasConceptScore W2089940930C2778840127 @default.
• W2089940930 hasConceptScore W2089940930C2993291352 @default.
• W2089940930 hasConceptScore W2089940930C526584372 @default.
• W2089940930 hasConceptScore W2089940930C71315377 @default.
• W2089940930 hasConceptScore W2089940930C71924100 @default.
• W2089940930 hasIssue "10" @default.
• W2089940930 hasLocation W20899409301 @default.

• next