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- W2089948246 abstract "The beginning of the millennium saw the discovery of a new bone-matrix protein, Matrix Extracellular PhosphoglycoprotEin (MEPE) and an associated C-terminal motif called ASARM. This motif and other distinguishing features occur in a group of proteins called SIBLINGs. These proteins include dentin matrix protein 1 (DMP1), osteopontin, dentin-sialophosphoprotein (DSPP), statherin, bone sialoprotein (BSP) and MEPE. MEPE, DMP1 and ASARM-motifs regulate expression of a phosphate regulating cytokine FGF23. Further, a trimeric interaction between phosphate regulating endopeptidase homolog X-linked (PHEX), DMP1, and α5β3-integrin that occurs on the plasma-membrane of the osteocyte mediates FGF23 regulation (FAP pathway). ASARM-peptides competitively inhibit the trimeric complex and increase FGF23. A second pathway involves specialized structures, matrix vesicles pathway (MVP). This review will discuss the FAP and MVP pathways and present a unified model for mineral and energy metabolism." @default.
- W2089948246 created "2016-06-24" @default.
- W2089948246 creator A5039325504 @default.
- W2089948246 date "2015-06-01" @default.
- W2089948246 modified "2023-09-25" @default.
- W2089948246 title "A unified model for bone–renal mineral and energy metabolism" @default.
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- W2089948246 doi "https://doi.org/10.1016/j.coph.2015.03.006" @default.
- W2089948246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4470732" @default.
- W2089948246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25880364" @default.
- W2089948246 hasPublicationYear "2015" @default.
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