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- W2089959968 abstract "It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders." @default.
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- W2089959968 date "2005-11-01" @default.
- W2089959968 modified "2023-10-13" @default.
- W2089959968 title "Autism spectrum disorders associated with X chromosome markers in French-Canadian males" @default.
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- W2089959968 doi "https://doi.org/10.1038/sj.mp.4001756" @default.
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