FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089966733> ?p ?o ?g. }

• W2089966733 endingPage "6844" @default.
• W2089966733 startingPage "6835" @default.
• W2089966733 abstract "Statistical HeterospectroscopY (SHY) is a statistical strategy for the coanalysis of multiple spectroscopic data sets acquired in parallel on the same samples. This method operates through the analysis of the intrinsic covariance between signal intensities in the same and related molecular fingerprints measured by multiple spectroscopic techniques across cohorts of samples. Here, the method is applied to 600-MHz 1H NMR and UPLC-TOF-MSE data obtained from human urine samples (n = 86) from a subset of an epidemiological population unselected for any relevant phenotype or disease factor. We show that direct cross-correlation of spectral parameters, viz. chemical shifts from NMR and m/z data from MS, together with fragment analysis from MSE scans, leads not only to the detection of numerous endogenous urinary metabolites but also the identification of drug metabolites that are part of the latent use of drugs by the population. We show previously unreported positive mode ions of ibuprofen metabolites with their NMR correlates and suggest the detection of new metabolites of disopyramide in the population samples. This approach is of great potential value in the description of population xenometabolomes and in population pharmacology studies, and indeed for drug metabolism studies in general." @default.
• W2089966733 created "2016-06-24" @default.
• W2089966733 creator A5006399424 @default.
• W2089966733 creator A5018207002 @default.
• W2089966733 creator A5023955658 @default.
• W2089966733 creator A5038447689 @default.
• W2089966733 creator A5068136783 @default.
• W2089966733 creator A5082249458 @default.
• W2089966733 creator A5088576480 @default.
• W2089966733 date "2008-08-14" @default.
• W2089966733 modified "2023-10-09" @default.
• W2089966733 title "¹H NMR and UPLC-MS^E Statistical Heterospectroscopy: Characterization of Drug Metabolites (Xenometabolome) in Epidemiological Studies" @default.
• W2089966733 cites W1761787460 @default.
• W2089966733 cites W1926141990 @default.
• W2089966733 cites W1966854042 @default.
• W2089966733 cites W1977229406 @default.
• W2089966733 cites W1977355631 @default.
• W2089966733 cites W1978461542 @default.
• W2089966733 cites W1978896527 @default.
• W2089966733 cites W1982772252 @default.
• W2089966733 cites W1984420356 @default.
• W2089966733 cites W1985258509 @default.
• W2089966733 cites W1992611102 @default.
• W2089966733 cites W1993652628 @default.
• W2089966733 cites W1994397833 @default.
• W2089966733 cites W2001149627 @default.
• W2089966733 cites W2001383141 @default.
• W2089966733 cites W2008262185 @default.
• W2089966733 cites W2010407069 @default.
• W2089966733 cites W2010744192 @default.
• W2089966733 cites W2013490552 @default.
• W2089966733 cites W2016914303 @default.
• W2089966733 cites W2019950587 @default.
• W2089966733 cites W2020572935 @default.
• W2089966733 cites W2022173743 @default.
• W2089966733 cites W2022778860 @default.
• W2089966733 cites W2051366884 @default.
• W2089966733 cites W2055398626 @default.
• W2089966733 cites W2068439954 @default.
• W2089966733 cites W2069724959 @default.
• W2089966733 cites W2070817507 @default.
• W2089966733 cites W2073039202 @default.
• W2089966733 cites W2074082728 @default.
• W2089966733 cites W2075746850 @default.
• W2089966733 cites W2076755375 @default.
• W2089966733 cites W2084497950 @default.
• W2089966733 cites W2086251769 @default.
• W2089966733 cites W2086948997 @default.
• W2089966733 cites W2101869972 @default.
• W2089966733 cites W2108488321 @default.
• W2089966733 cites W2115974175 @default.
• W2089966733 cites W2116184147 @default.
• W2089966733 cites W2120568649 @default.
• W2089966733 cites W2122259188 @default.
• W2089966733 cites W2145999389 @default.
• W2089966733 cites W2148762320 @default.
• W2089966733 cites W4302590696 @default.
• W2089966733 doi "https://doi.org/10.1021/ac801075m" @default.
• W2089966733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18700783" @default.
• W2089966733 hasPublicationYear "2008" @default.
• W2089966733 type Work @default.
• W2089966733 sameAs 2089966733 @default.
• W2089966733 citedByCount "77" @default.
• W2089966733 countsByYear W20899667332012 @default.
• W2089966733 countsByYear W20899667332013 @default.
• W2089966733 countsByYear W20899667332014 @default.
• W2089966733 countsByYear W20899667332015 @default.
• W2089966733 countsByYear W20899667332016 @default.
• W2089966733 countsByYear W20899667332017 @default.
• W2089966733 countsByYear W20899667332018 @default.
• W2089966733 countsByYear W20899667332019 @default.
• W2089966733 countsByYear W20899667332020 @default.
• W2089966733 countsByYear W20899667332021 @default.
• W2089966733 countsByYear W20899667332022 @default.
• W2089966733 crossrefType "journal-article" @default.
• W2089966733 hasAuthorship W2089966733A5006399424 @default.
• W2089966733 hasAuthorship W2089966733A5018207002 @default.
• W2089966733 hasAuthorship W2089966733A5023955658 @default.
• W2089966733 hasAuthorship W2089966733A5038447689 @default.
• W2089966733 hasAuthorship W2089966733A5068136783 @default.
• W2089966733 hasAuthorship W2089966733A5082249458 @default.
• W2089966733 hasAuthorship W2089966733A5088576480 @default.
• W2089966733 hasConcept C111429119 @default.
• W2089966733 hasConcept C144024400 @default.
• W2089966733 hasConcept C147789679 @default.
• W2089966733 hasConcept C149923435 @default.
• W2089966733 hasConcept C185592680 @default.
• W2089966733 hasConcept C21565614 @default.
• W2089966733 hasConcept C2777477808 @default.
• W2089966733 hasConcept C2908647359 @default.
• W2089966733 hasConcept C43617362 @default.
• W2089966733 hasConcept C55493867 @default.
• W2089966733 hasConceptScore W2089966733C111429119 @default.
• W2089966733 hasConceptScore W2089966733C144024400 @default.
• W2089966733 hasConceptScore W2089966733C147789679 @default.
• W2089966733 hasConceptScore W2089966733C149923435 @default.
• W2089966733 hasConceptScore W2089966733C185592680 @default.
• W2089966733 hasConceptScore W2089966733C21565614 @default.

• next