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- W2089968107 abstract "A great paradox in cellular immunology is how T cell allorecognition exists at high frequencies (up to 10%) despite the stringent requirements of discriminating 'self' from 'non-self' imposed by MHC restriction. Thus, in tissue transplantation, a substantial proportion of the recipient's T cells will have the ability to recognize the graft and instigate an immune response against the transplanted tissue, ultimately resulting in graft rejection--a manifestation of T cell alloreactivity. Transplantation of human organs and lymphoid cells as treatment for otherwise life-threatening diseases has become a more routine medical procedure making this problem of great importance. Immunologists have gained important insights into the mechanisms of T cell alloreactivity from cytotoxic T cell assays, affinity-avidity studies, and crystal structures of peptide-MHC (pMHC) molecules and T cell receptors (TCRs) both alone and in complex. Despite the clinical significance of alloreactivity, the crystal structure of an alloreactive human TCR in complex with both cognate pMHC and an allogeneic pMHC complex has yet to be determined. This review highlights some of the important findings from studies characterizing the way in which alloreactive T cell receptors and pMHC molecules interact in an attempt to resolve this great irony of the cellular immune response." @default.
- W2089968107 created "2016-06-24" @default.
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- W2089968107 date "2008-02-01" @default.
- W2089968107 modified "2023-09-23" @default.
- W2089968107 title "T cell allorecognition and MHC restriction—A case of Jekyll and Hyde?" @default.
- W2089968107 cites W1487735178 @default.
- W2089968107 cites W1492543509 @default.
- W2089968107 cites W1495105223 @default.
- W2089968107 cites W1528487587 @default.
- W2089968107 cites W1531269451 @default.
- W2089968107 cites W15483175 @default.
- W2089968107 cites W1548757996 @default.
- W2089968107 cites W1589083431 @default.
- W2089968107 cites W1602822883 @default.
- W2089968107 cites W1607752827 @default.
- W2089968107 cites W1630218117 @default.
- W2089968107 cites W1720916191 @default.
- W2089968107 cites W1855822212 @default.
- W2089968107 cites W1887482810 @default.
- W2089968107 cites W193514409 @default.
- W2089968107 cites W1957876511 @default.
- W2089968107 cites W1964964271 @default.
- W2089968107 cites W1965342739 @default.
- W2089968107 cites W1965986127 @default.
- W2089968107 cites W1971439809 @default.
- W2089968107 cites W1973278095 @default.
- W2089968107 cites W1975184547 @default.
- W2089968107 cites W1975673392 @default.
- W2089968107 cites W1976301796 @default.
- W2089968107 cites W1977048108 @default.
- W2089968107 cites W1979262763 @default.
- W2089968107 cites W1983760021 @default.
- W2089968107 cites W1985774274 @default.
- W2089968107 cites W1990395260 @default.
- W2089968107 cites W1995593914 @default.
- W2089968107 cites W1996350333 @default.
- W2089968107 cites W1996594154 @default.
- W2089968107 cites W1998548282 @default.
- W2089968107 cites W2000045443 @default.
- W2089968107 cites W2001064691 @default.
- W2089968107 cites W2002113738 @default.
- W2089968107 cites W2003772918 @default.
- W2089968107 cites W2004618581 @default.
- W2089968107 cites W2005096752 @default.
- W2089968107 cites W2007211891 @default.
- W2089968107 cites W2008557466 @default.
- W2089968107 cites W2008744347 @default.
- W2089968107 cites W2009907090 @default.
- W2089968107 cites W2010309262 @default.
- W2089968107 cites W2012229899 @default.
- W2089968107 cites W2012541213 @default.
- W2089968107 cites W2014946585 @default.
- W2089968107 cites W2020552454 @default.
- W2089968107 cites W2020599427 @default.
- W2089968107 cites W2021673674 @default.
- W2089968107 cites W2021922884 @default.
- W2089968107 cites W2023201913 @default.
- W2089968107 cites W2024689720 @default.
- W2089968107 cites W2028277782 @default.
- W2089968107 cites W2029993034 @default.
- W2089968107 cites W2030085696 @default.
- W2089968107 cites W2031011895 @default.
- W2089968107 cites W2031057215 @default.
- W2089968107 cites W2032428654 @default.
- W2089968107 cites W2033592208 @default.
- W2089968107 cites W2036244559 @default.
- W2089968107 cites W2036419095 @default.
- W2089968107 cites W2036785154 @default.
- W2089968107 cites W2040289923 @default.
- W2089968107 cites W2042371846 @default.
- W2089968107 cites W2045010575 @default.
- W2089968107 cites W2047747639 @default.
- W2089968107 cites W2048784307 @default.
- W2089968107 cites W2052321000 @default.
- W2089968107 cites W2052383501 @default.
- W2089968107 cites W2055114864 @default.
- W2089968107 cites W2060808583 @default.
- W2089968107 cites W2063346300 @default.
- W2089968107 cites W2069871829 @default.
- W2089968107 cites W2069874313 @default.
- W2089968107 cites W2071021373 @default.
- W2089968107 cites W2071549635 @default.
- W2089968107 cites W2072824343 @default.
- W2089968107 cites W2074222872 @default.
- W2089968107 cites W2076058809 @default.
- W2089968107 cites W2077215890 @default.
- W2089968107 cites W2077861376 @default.
- W2089968107 cites W2077864494 @default.
- W2089968107 cites W2079453672 @default.
- W2089968107 cites W2080067734 @default.
- W2089968107 cites W2080956086 @default.