FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089968342> ?p ?o ?g. }

• W2089968342 abstract "Previous studies in guinea pigs have shown that while a serotonin 5-HT(1B/D) receptor agonist, GR46611, does not induce locomotor activation when given alone, it markedly enhances the locomotor response to selective 5-HT(1A) receptor agonists, 8-OH-DPAT and buspirone. In these studies, we found that another 5-HT(1B/D) agonist, 3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate (SKF99101H), significantly elevated locomotor activity in guinea pigs when given alone. We assessed the relative contribution of 5-HT1(1A) and 5-HT(1B/D) receptors in the mediation of this effect. Activity was measured by photobeam interrupts in opaque Perspex cylinders linked to a computer. SKF99101H (20 mg/kg s. c.) significantly increased the locomotor activity in guinea pigs. The locomotor stimulant effect of SKF99101H (20 mg/kg s.c) was reversed by the selective 5-HT(1B/D) receptor antagonist N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2'-methyl-4'-(5-methyl -1,2,4-oxadiazol-3-yl)[1,1biphenyl]4-carboxamide (GR127935; 0.06-0. 25 mg/kg s.c.). The 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride (WAY100635; 0.05-0.25 mg/kg s.c.), slightly but significantly attenuated the hyperactivity induced by SKF99101H. These findings suggest that 5-HT(1B/D) receptor agonists may require concomitant activation of 5-HT(1A) receptors to induce locomotor activity in guinea pigs. The 5-HT(2A) receptor antagonist 6[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]-ethyl]-7-methyl- 5H-thiazol[3,2-a]pyrimidin-5-one (ritanserin) had no effect on SKF99101H-induced hyperactivity, suggesting that these receptors are not involved in the mediation of SKF99101H-induced hyperactivity. SKF99101H-induced hyperactivity was significantly attenuated by the D(1) dopamine receptor antagonist SCH 23390 (0.005-025 mg/kg), but not by the D(2) dopamine receptor antagonist raclopride (0.25-1.0 mg/kg), possibly suggesting the selective involvement of D(1) dopaminergic receptors in the mediation of the stimulant actions of the 5-HT(1B/D) agonist." @default.
• W2089968342 created "2016-06-24" @default.
• W2089968342 creator A5003114639 @default.
• W2089968342 creator A5024281089 @default.
• W2089968342 creator A5012045256 @default.
• W2089968342 date "2000-06-01" @default.
• W2089968342 modified "2023-09-26" @default.
• W2089968342 title "5-HT1B/D receptor agonist, SKF99101H, induces locomotor hyperactivity in the guinea pig" @default.
• W2089968342 cites W1597053236 @default.
• W2089968342 cites W1963690073 @default.
• W2089968342 cites W1964030516 @default.
• W2089968342 cites W1966579748 @default.
• W2089968342 cites W1969957805 @default.
• W2089968342 cites W1991650720 @default.
• W2089968342 cites W1998686023 @default.
• W2089968342 cites W2004047042 @default.
• W2089968342 cites W2020547623 @default.
• W2089968342 cites W2022686134 @default.
• W2089968342 cites W2038946536 @default.
• W2089968342 cites W2049691147 @default.
• W2089968342 cites W2057924185 @default.
• W2089968342 cites W2058715186 @default.
• W2089968342 cites W2058943943 @default.
• W2089968342 cites W2071176207 @default.
• W2089968342 cites W2072266462 @default.
• W2089968342 cites W2075434858 @default.
• W2089968342 cites W2083525343 @default.
• W2089968342 cites W2084253035 @default.
• W2089968342 cites W2092736757 @default.
• W2089968342 cites W2093249511 @default.
• W2089968342 cites W2109489609 @default.
• W2089968342 cites W2112681800 @default.
• W2089968342 cites W2138538218 @default.
• W2089968342 doi "https://doi.org/10.1016/s0014-2999(00)00345-9" @default.
• W2089968342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10876022" @default.
• W2089968342 hasPublicationYear "2000" @default.
• W2089968342 type Work @default.
• W2089968342 sameAs 2089968342 @default.
• W2089968342 citedByCount "5" @default.
• W2089968342 crossrefType "journal-article" @default.
• W2089968342 hasAuthorship W2089968342A5003114639 @default.
• W2089968342 hasAuthorship W2089968342A5012045256 @default.
• W2089968342 hasAuthorship W2089968342A5024281089 @default.
• W2089968342 hasConcept C126322002 @default.
• W2089968342 hasConcept C134018914 @default.
• W2089968342 hasConcept C170493617 @default.
• W2089968342 hasConcept C185592680 @default.
• W2089968342 hasConcept C2775864247 @default.
• W2089968342 hasConcept C2776885963 @default.
• W2089968342 hasConcept C2778122271 @default.
• W2089968342 hasConcept C2778815084 @default.
• W2089968342 hasConcept C2778938600 @default.
• W2089968342 hasConcept C2780557958 @default.
• W2089968342 hasConcept C2781093953 @default.
• W2089968342 hasConcept C53910766 @default.
• W2089968342 hasConcept C58732023 @default.
• W2089968342 hasConcept C71924100 @default.
• W2089968342 hasConcept C86803240 @default.
• W2089968342 hasConcept C98274493 @default.
• W2089968342 hasConceptScore W2089968342C126322002 @default.
• W2089968342 hasConceptScore W2089968342C134018914 @default.
• W2089968342 hasConceptScore W2089968342C170493617 @default.
• W2089968342 hasConceptScore W2089968342C185592680 @default.
• W2089968342 hasConceptScore W2089968342C2775864247 @default.
• W2089968342 hasConceptScore W2089968342C2776885963 @default.
• W2089968342 hasConceptScore W2089968342C2778122271 @default.
• W2089968342 hasConceptScore W2089968342C2778815084 @default.
• W2089968342 hasConceptScore W2089968342C2778938600 @default.
• W2089968342 hasConceptScore W2089968342C2780557958 @default.
• W2089968342 hasConceptScore W2089968342C2781093953 @default.
• W2089968342 hasConceptScore W2089968342C53910766 @default.
• W2089968342 hasConceptScore W2089968342C58732023 @default.
• W2089968342 hasConceptScore W2089968342C71924100 @default.
• W2089968342 hasConceptScore W2089968342C86803240 @default.
• W2089968342 hasConceptScore W2089968342C98274493 @default.
• W2089968342 hasLocation W20899683421 @default.
• W2089968342 hasLocation W20899683422 @default.
• W2089968342 hasOpenAccess W2089968342 @default.
• W2089968342 hasPrimaryLocation W20899683421 @default.
• W2089968342 hasRelatedWork W1895729847 @default.
• W2089968342 hasRelatedWork W1969957805 @default.
• W2089968342 hasRelatedWork W1971395727 @default.
• W2089968342 hasRelatedWork W1984962861 @default.
• W2089968342 hasRelatedWork W1986980508 @default.
• W2089968342 hasRelatedWork W1991650720 @default.
• W2089968342 hasRelatedWork W1992935336 @default.
• W2089968342 hasRelatedWork W2011685436 @default.
• W2089968342 hasRelatedWork W2011986757 @default.
• W2089968342 hasRelatedWork W2022686134 @default.
• W2089968342 hasRelatedWork W2024751011 @default.
• W2089968342 hasRelatedWork W2025678690 @default.
• W2089968342 hasRelatedWork W2051310269 @default.
• W2089968342 hasRelatedWork W2057478907 @default.
• W2089968342 hasRelatedWork W2083525343 @default.
• W2089968342 hasRelatedWork W2084498341 @default.
• W2089968342 hasRelatedWork W2092593150 @default.
• W2089968342 hasRelatedWork W2092736757 @default.
• W2089968342 hasRelatedWork W2099797657 @default.
• W2089968342 hasRelatedWork W2369956047 @default.
• W2089968342 isParatext "false" @default.

• next