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- W2089968377 abstract "Many of the physiological effects of nitric oxide are mediated by activation of soluble guanylyl cyclase, resulting in cellular cGMP accumulation. In the 1990s, the benzylindazole derivative YC-1 was identified as a novel modulator of cGMP signalling that exerted complex actions in a NO-independent manner. A recent study describes a high-affinity YC-1 analogue that decreases blood pressure in hypertensive rats and increases bleeding time, which suggests that this drug might have therapeutic potential as a vasodilator with antiplatelet activity." @default.
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- W2089968377 date "2001-11-01" @default.
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- W2089968377 title "cGMP signalling beyond nitric oxide" @default.
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- W2089968377 doi "https://doi.org/10.1016/s0165-6147(00)01889-7" @default.
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