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- W2089968389 abstract "Atherosclerosis is a ubiquitous, complex disease process, which is dynamic and multifactorial. Genetic and environmental factors and their interactions lead to the initiation and progression of atherosclerosis over decades. The vascular endothelium, as the largest paracrine organ, maintains vascular health and initiates the atherosclerotic process when injured. Strategically located between the vessel lumen and smooth muscle layer, the endothelium modulates vascular tone, cell growth, platelet and leukocyte interactions, thrombogenicity, and inflammation. Physical and chemical stimuli in the vascular milieu initiate diverse physiologic processes through complex signal transduction mechanisms that are not yet fully understood, by the elaboration and secretion of various substances. The magnitude and duration of exposure to cardiovascular risk factors lead to vascular injury through oxidative stress mechanisms, which ultimately lead to a procoagulant, proinflammatory, and vasoconstrictive state. Moreover, this promotes oxidation of low-density lipoprotein and proliferation of cell growth." @default.
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- W2089968389 date "2004-06-01" @default.
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- W2089968389 title "Brachial artery reactivity: clinical tool or research toy?" @default.
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- W2089968389 doi "https://doi.org/10.1016/j.echo.2004.03.016" @default.
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