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• W2089968648 abstract "Morphological hallmarks of inflammatory and degenerative diseases of the brain are hypertrophy of astrocytes and accumulation of macrophages recruited from circulating blood monocytes and/or from resident macrophages, the so-called microglial cells. Recently, production of granulocyte-macrophage colony-stimulating factor (GM-CSF) by astrocytes has been suggested to contribute to the macrophage response. Here we report that in addition to GM-CSF, murine astrocytes also produce macrophage (M)-CSF upon stimulation with tumor necrosis factor alpha, interleukin-1 and lipopolysaccharides. The bioactivity detected in supernatant of astrocytes was characterized using the M-CSF-dependent cell line M-NFS-60 and neutralizing anti-M-CSF antibodies. RNase protection analysis showed M-CSF mRNA already in unstimulated astrocytes without striking up-regulation by the stimuli. Thus, in astrocytes the expression of the M-CSF gene is predominantly regulated at the posttranscriptional level." @default.
• W2089968648 created "2016-06-24" @default.
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• W2089968648 date "1992-10-01" @default.
• W2089968648 modified "2023-09-28" @default.
• W2089968648 title "Production of macrophage colony-stimulating factor by astrocytes and brain macrophages" @default.
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• W2089968648 doi "https://doi.org/10.1016/0165-5728(92)90133-6" @default.
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