FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089969351> ?p ?o ?g. }

• W2089969351 endingPage "40" @default.
• W2089969351 startingPage "34" @default.
• W2089969351 abstract "The conversion of testosterone to 5α-dihydrotestosterone by the enzyme 5α-reductase is inhibited by finasteride. In a study in which maternal dosing with finasteride commenced on Gestational Day 15 and terminated on Postpartum Day 21, there were 13 and 27% decreases in anogenital distance of male pups on Postnatal Day 1 at 0.03 and 3 mg/kg/day, respectively. These decreases were largely reversed by Postnatal Day 22 even though treatment of the dams continued. Treatment at 3 mg/kg/day also resulted in hypospadias with cleft prepuce and a 5-day delay in the separation of the prepuce from the glans penis in those animals without hypospadias. A second study in which 20 mg/kg/day finasteride was administered on successive 2-day periods during late gestation in rats demonstrated that the period of Gestational Days 16 to 17 was the most sensitive (critical period) for finasteride-induced hypospadias, cleft prepuce, decreased anogenital distance, reduced prostate weight, and nipple formation in F1 male offspring. This critical period is just prior to the appearance on Day 18 of gestation of a midline mesenchymal plate between the urogenital sinus and the rectum in normal male fetuses. This midline plate does not appear in finasteride-exposed fetuses destined to have hypospadias as demonstrated in a previous study. Based on these observations. we hypothesize that finasteride causes hypospadias by preventing the formation of the medial mesenchymal plate which is necessary for assisting the movement of the urogenital sinus from the base to the tip of the genital tubercle." @default.
• W2089969351 created "2016-06-24" @default.
• W2089969351 creator A5006113825 @default.
• W2089969351 creator A5031182905 @default.
• W2089969351 creator A5037183790 @default.
• W2089969351 creator A5039193505 @default.
• W2089969351 creator A5045069972 @default.
• W2089969351 creator A5054174434 @default.
• W2089969351 creator A5070800219 @default.
• W2089969351 creator A5071748121 @default.
• W2089969351 date "1993-03-01" @default.
• W2089969351 modified "2023-09-27" @default.
• W2089969351 title "Critical Developmental Periods for Effects on Male Rat Genitalia Induced by Finasteride, a 5α-Reductase Inhibitor" @default.
• W2089969351 doi "https://doi.org/10.1006/taap.1993.1041" @default.
• W2089969351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8385814" @default.
• W2089969351 hasPublicationYear "1993" @default.
• W2089969351 type Work @default.
• W2089969351 sameAs 2089969351 @default.
• W2089969351 citedByCount "86" @default.
• W2089969351 countsByYear W20899693512012 @default.
• W2089969351 countsByYear W20899693512014 @default.
• W2089969351 countsByYear W20899693512015 @default.
• W2089969351 countsByYear W20899693512016 @default.
• W2089969351 countsByYear W20899693512017 @default.
• W2089969351 countsByYear W20899693512018 @default.
• W2089969351 countsByYear W20899693512019 @default.
• W2089969351 countsByYear W20899693512020 @default.
• W2089969351 countsByYear W20899693512021 @default.
• W2089969351 crossrefType "journal-article" @default.
• W2089969351 hasAuthorship W2089969351A5006113825 @default.
• W2089969351 hasAuthorship W2089969351A5031182905 @default.
• W2089969351 hasAuthorship W2089969351A5037183790 @default.
• W2089969351 hasAuthorship W2089969351A5039193505 @default.
• W2089969351 hasAuthorship W2089969351A5045069972 @default.
• W2089969351 hasAuthorship W2089969351A5054174434 @default.
• W2089969351 hasAuthorship W2089969351A5070800219 @default.
• W2089969351 hasAuthorship W2089969351A5071748121 @default.
• W2089969351 hasConcept C105702510 @default.
• W2089969351 hasConcept C112672928 @default.
• W2089969351 hasConcept C121608353 @default.
• W2089969351 hasConcept C126322002 @default.
• W2089969351 hasConcept C134018914 @default.
• W2089969351 hasConcept C16685009 @default.
• W2089969351 hasConcept C172680121 @default.
• W2089969351 hasConcept C201614185 @default.
• W2089969351 hasConcept C2775874879 @default.
• W2089969351 hasConcept C2776235491 @default.
• W2089969351 hasConcept C2777050469 @default.
• W2089969351 hasConcept C2777668474 @default.
• W2089969351 hasConcept C2777786686 @default.
• W2089969351 hasConcept C2777911890 @default.
• W2089969351 hasConcept C2777990738 @default.
• W2089969351 hasConcept C2779234561 @default.
• W2089969351 hasConcept C2779279991 @default.
• W2089969351 hasConcept C2779322244 @default.
• W2089969351 hasConcept C2779881493 @default.
• W2089969351 hasConcept C46973012 @default.
• W2089969351 hasConcept C54355233 @default.
• W2089969351 hasConcept C71315377 @default.
• W2089969351 hasConcept C71924100 @default.
• W2089969351 hasConcept C86803240 @default.
• W2089969351 hasConceptScore W2089969351C105702510 @default.
• W2089969351 hasConceptScore W2089969351C112672928 @default.
• W2089969351 hasConceptScore W2089969351C121608353 @default.
• W2089969351 hasConceptScore W2089969351C126322002 @default.
• W2089969351 hasConceptScore W2089969351C134018914 @default.
• W2089969351 hasConceptScore W2089969351C16685009 @default.
• W2089969351 hasConceptScore W2089969351C172680121 @default.
• W2089969351 hasConceptScore W2089969351C201614185 @default.
• W2089969351 hasConceptScore W2089969351C2775874879 @default.
• W2089969351 hasConceptScore W2089969351C2776235491 @default.
• W2089969351 hasConceptScore W2089969351C2777050469 @default.
• W2089969351 hasConceptScore W2089969351C2777668474 @default.
• W2089969351 hasConceptScore W2089969351C2777786686 @default.
• W2089969351 hasConceptScore W2089969351C2777911890 @default.
• W2089969351 hasConceptScore W2089969351C2777990738 @default.
• W2089969351 hasConceptScore W2089969351C2779234561 @default.
• W2089969351 hasConceptScore W2089969351C2779279991 @default.
• W2089969351 hasConceptScore W2089969351C2779322244 @default.
• W2089969351 hasConceptScore W2089969351C2779881493 @default.
• W2089969351 hasConceptScore W2089969351C46973012 @default.
• W2089969351 hasConceptScore W2089969351C54355233 @default.
• W2089969351 hasConceptScore W2089969351C71315377 @default.
• W2089969351 hasConceptScore W2089969351C71924100 @default.
• W2089969351 hasConceptScore W2089969351C86803240 @default.
• W2089969351 hasIssue "1" @default.
• W2089969351 hasLocation W20899693511 @default.
• W2089969351 hasLocation W20899693512 @default.
• W2089969351 hasOpenAccess W2089969351 @default.
• W2089969351 hasPrimaryLocation W20899693511 @default.
• W2089969351 hasRelatedWork W1979102595 @default.
• W2089969351 hasRelatedWork W1979452793 @default.
• W2089969351 hasRelatedWork W1981433740 @default.
• W2089969351 hasRelatedWork W2000206763 @default.
• W2089969351 hasRelatedWork W2011393343 @default.
• W2089969351 hasRelatedWork W2039466440 @default.
• W2089969351 hasRelatedWork W2083564258 @default.
• W2089969351 hasRelatedWork W2089969351 @default.

• next