FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089970563> ?p ?o ?g. }

• W2089970563 endingPage "163" @default.
• W2089970563 startingPage "157" @default.
• W2089970563 abstract "The present study determined the differential effects of unilateral striatal dopamine depletion on cranial motor versus limb motor function. Forty male Long Evans rats were first trained on a comprehensive motor testing battery that dissociated cranial versus limb motor function and included: cylinder forepaw placement, single pellet reaching, vermicelli pasta handling; sunflower seed opening, pasta biting acoustics, and a licking task. Following baseline testing, animals were randomized to either a 6-hydroxydopamine (6-OHDA) (n=20) or control (n=20) group. Animals in the 6-OHDA group received unilateral intrastriatal 6-OHDA infusions to induce striatal dopamine depletion. Six-weeks following infusion, all animals were re-tested on the same battery of motor tests. Near infrared densitometry was performed on sections taken through the striatum that were immunohistochemically stained for tyrosine hydroxylase (TH). Animals in the 6-OHDA condition showed a mean reduction in TH staining of 88.27%. Although 6-OHDA animals were significantly impaired on all motor tasks, limb motor deficits were more severe than cranial motor impairments. Further, performance on limb motor tasks was correlated with degree of TH depletion while performance on cranial motor impairments showed no significant correlation. These results suggest that limb motor function may be more sensitive to striatal dopaminergic depletion than cranial motor function and is consistent with the clinical observation that therapies targeting the nigrostriatal dopaminergic system in Parkinson's disease are more effective for limb motor symptoms than cranial motor impairments." @default.
• W2089970563 created "2016-06-24" @default.
• W2089970563 creator A5002673170 @default.
• W2089970563 creator A5009475620 @default.
• W2089970563 creator A5013817999 @default.
• W2089970563 creator A5024363243 @default.
• W2089970563 creator A5044537776 @default.
• W2089970563 creator A5055291900 @default.
• W2089970563 creator A5056072835 @default.
• W2089970563 creator A5074834771 @default.
• W2089970563 creator A5083267494 @default.
• W2089970563 date "2013-01-01" @default.
• W2089970563 modified "2023-10-18" @default.
• W2089970563 title "Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion" @default.
• W2089970563 cites W1540549793 @default.
• W2089970563 cites W1572276522 @default.
• W2089970563 cites W1801340045 @default.
• W2089970563 cites W1874219366 @default.
• W2089970563 cites W1966260988 @default.
• W2089970563 cites W1974898145 @default.
• W2089970563 cites W1976652631 @default.
• W2089970563 cites W1979480763 @default.
• W2089970563 cites W1982349791 @default.
• W2089970563 cites W1986111479 @default.
• W2089970563 cites W1986893503 @default.
• W2089970563 cites W1991304179 @default.
• W2089970563 cites W1997531277 @default.
• W2089970563 cites W1999385317 @default.
• W2089970563 cites W2007697742 @default.
• W2089970563 cites W2008324666 @default.
• W2089970563 cites W2012378062 @default.
• W2089970563 cites W2015668244 @default.
• W2089970563 cites W2016109926 @default.
• W2089970563 cites W2019256317 @default.
• W2089970563 cites W2030986484 @default.
• W2089970563 cites W2044842134 @default.
• W2089970563 cites W2046422011 @default.
• W2089970563 cites W2048975170 @default.
• W2089970563 cites W2079255181 @default.
• W2089970563 cites W2079342559 @default.
• W2089970563 cites W2084770399 @default.
• W2089970563 cites W2095270577 @default.
• W2089970563 cites W2107574028 @default.
• W2089970563 cites W2108231900 @default.
• W2089970563 cites W2127129865 @default.
• W2089970563 cites W2133532809 @default.
• W2089970563 cites W2137898821 @default.
• W2089970563 cites W2160180857 @default.
• W2089970563 cites W2160457789 @default.
• W2089970563 cites W4244914531 @default.
• W2089970563 cites W4251838923 @default.
• W2089970563 doi "https://doi.org/10.1016/j.bbr.2012.09.031" @default.
• W2089970563 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3614355" @default.
• W2089970563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23018122" @default.
• W2089970563 hasPublicationYear "2013" @default.
• W2089970563 type Work @default.
• W2089970563 sameAs 2089970563 @default.
• W2089970563 citedByCount "18" @default.
• W2089970563 countsByYear W20899705632013 @default.
• W2089970563 countsByYear W20899705632014 @default.
• W2089970563 countsByYear W20899705632015 @default.
• W2089970563 countsByYear W20899705632016 @default.
• W2089970563 countsByYear W20899705632017 @default.
• W2089970563 countsByYear W20899705632018 @default.
• W2089970563 countsByYear W20899705632019 @default.
• W2089970563 countsByYear W20899705632020 @default.
• W2089970563 countsByYear W20899705632021 @default.
• W2089970563 countsByYear W20899705632022 @default.
• W2089970563 countsByYear W20899705632023 @default.
• W2089970563 crossrefType "journal-article" @default.
• W2089970563 hasAuthorship W2089970563A5002673170 @default.
• W2089970563 hasAuthorship W2089970563A5009475620 @default.
• W2089970563 hasAuthorship W2089970563A5013817999 @default.
• W2089970563 hasAuthorship W2089970563A5024363243 @default.
• W2089970563 hasAuthorship W2089970563A5044537776 @default.
• W2089970563 hasAuthorship W2089970563A5055291900 @default.
• W2089970563 hasAuthorship W2089970563A5056072835 @default.
• W2089970563 hasAuthorship W2089970563A5074834771 @default.
• W2089970563 hasAuthorship W2089970563A5083267494 @default.
• W2089970563 hasBestOaLocation W20899705632 @default.
• W2089970563 hasConcept C137183658 @default.
• W2089970563 hasConcept C15744967 @default.
• W2089970563 hasConcept C169760540 @default.
• W2089970563 hasConcept C2776355744 @default.
• W2089970563 hasConcept C2780062018 @default.
• W2089970563 hasConcept C2780938664 @default.
• W2089970563 hasConcept C513476851 @default.
• W2089970563 hasConcept C71924100 @default.
• W2089970563 hasConceptScore W2089970563C137183658 @default.
• W2089970563 hasConceptScore W2089970563C15744967 @default.
• W2089970563 hasConceptScore W2089970563C169760540 @default.
• W2089970563 hasConceptScore W2089970563C2776355744 @default.
• W2089970563 hasConceptScore W2089970563C2780062018 @default.
• W2089970563 hasConceptScore W2089970563C2780938664 @default.
• W2089970563 hasConceptScore W2089970563C513476851 @default.
• W2089970563 hasConceptScore W2089970563C71924100 @default.
• W2089970563 hasLocation W20899705631 @default.
• W2089970563 hasLocation W20899705632 @default.

• next