FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2089973243> ?p ?o ?g. }

• W2089973243 endingPage "e9374" @default.
• W2089973243 startingPage "e9374" @default.
• W2089973243 abstract "Drosophila body wall muscles are multinucleated syncytia formed by successive fusions between a founder myoblast and several fusion competent myoblasts. Initial fusion gives rise to a bi/trinucleate precursor followed by more fusion cycles forming a mature muscle. This process requires the functions of various molecules including the transmembrane myoblast attractants Dumbfounded (Duf) and its paralogue Roughest (Rst), a scaffold protein Rolling pebbles (Rols) and a guanine nucleotide exchange factor Loner. Fusion completely fails in a duf, rst mutant, and is blocked at the bi/trinucleate stage in rols and loner single mutants. We analysed the transmembrane and intracellular domains of Duf, by mutating conserved putative signaling sites and serially deleting the intracellular domain. These were tested for their ability to translocate and interact with Rols and Loner and to rescue the fusion defect in duf, rst mutant embryos. Studying combinations of double mutants, further tested the function of Rols, Loner and other fusion molecules. Here we show that serial truncations of the Duf intracellular domain successively compromise its function to translocate and interact with Rols and Loner in addition to affecting myoblast fusion efficiency in embryos. Putative phosphorylation sites function additively while the extreme C terminus including a PDZ binding domain is dispensable for its function. We also show that fusion is completely blocked in a rols, loner double mutant and is compromised in other double mutants. These results suggest an additive function of the intracellular domain of Duf and an early function of Rols and Loner which is independent of Duf." @default.
• W2089973243 created "2016-06-24" @default.
• W2089973243 creator A5001435734 @default.
• W2089973243 creator A5002360670 @default.
• W2089973243 creator A5007222956 @default.
• W2089973243 creator A5044138798 @default.
• W2089973243 date "2010-02-23" @default.
• W2089973243 modified "2023-09-27" @default.
• W2089973243 title "The Intracellular Domain of Dumbfounded Affects Myoblast Fusion Efficiency and Interacts with Rolling Pebbles and Loner" @default.
• W2089973243 cites W1538224249 @default.
• W2089973243 cites W1608420792 @default.
• W2089973243 cites W1768818798 @default.
• W2089973243 cites W184514173 @default.
• W2089973243 cites W1950932417 @default.
• W2089973243 cites W1973131553 @default.
• W2089973243 cites W1997089228 @default.
• W2089973243 cites W1998213120 @default.
• W2089973243 cites W1998646925 @default.
• W2089973243 cites W2004850950 @default.
• W2089973243 cites W2009468127 @default.
• W2089973243 cites W2015059902 @default.
• W2089973243 cites W2020708064 @default.
• W2089973243 cites W2024691407 @default.
• W2089973243 cites W2039600491 @default.
• W2089973243 cites W2042524484 @default.
• W2089973243 cites W2048089231 @default.
• W2089973243 cites W2050020730 @default.
• W2089973243 cites W2053927358 @default.
• W2089973243 cites W2057845770 @default.
• W2089973243 cites W2062794845 @default.
• W2089973243 cites W2065993041 @default.
• W2089973243 cites W2075519455 @default.
• W2089973243 cites W2075967815 @default.
• W2089973243 cites W2089208780 @default.
• W2089973243 cites W2090306733 @default.
• W2089973243 cites W2092702781 @default.
• W2089973243 cites W2093545335 @default.
• W2089973243 cites W2098675511 @default.
• W2089973243 cites W2099283142 @default.
• W2089973243 cites W2106173158 @default.
• W2089973243 cites W2107740756 @default.
• W2089973243 cites W2108472247 @default.
• W2089973243 cites W2109628648 @default.
• W2089973243 cites W2110643873 @default.
• W2089973243 cites W2112652451 @default.
• W2089973243 cites W2114606496 @default.
• W2089973243 cites W2115657143 @default.
• W2089973243 cites W2134597119 @default.
• W2089973243 cites W2136812809 @default.
• W2089973243 cites W2157811844 @default.
• W2089973243 cites W2161851632 @default.
• W2089973243 cites W2169274584 @default.
• W2089973243 cites W2170157658 @default.
• W2089973243 cites W2181706898 @default.
• W2089973243 cites W2183111016 @default.
• W2089973243 cites W2187585640 @default.
• W2089973243 cites W4063809 @default.
• W2089973243 doi "https://doi.org/10.1371/journal.pone.0009374" @default.
• W2089973243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2826419" @default.
• W2089973243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20186342" @default.
• W2089973243 hasPublicationYear "2010" @default.
• W2089973243 type Work @default.
• W2089973243 sameAs 2089973243 @default.
• W2089973243 citedByCount "23" @default.
• W2089973243 countsByYear W20899732432012 @default.
• W2089973243 countsByYear W20899732432014 @default.
• W2089973243 countsByYear W20899732432015 @default.
• W2089973243 countsByYear W20899732432017 @default.
• W2089973243 countsByYear W20899732432018 @default.
• W2089973243 countsByYear W20899732432019 @default.
• W2089973243 countsByYear W20899732432020 @default.
• W2089973243 countsByYear W20899732432021 @default.
• W2089973243 countsByYear W20899732432022 @default.
• W2089973243 crossrefType "journal-article" @default.
• W2089973243 hasAuthorship W2089973243A5001435734 @default.
• W2089973243 hasAuthorship W2089973243A5002360670 @default.
• W2089973243 hasAuthorship W2089973243A5007222956 @default.
• W2089973243 hasAuthorship W2089973243A5044138798 @default.
• W2089973243 hasBestOaLocation W20899732431 @default.
• W2089973243 hasConcept C104317684 @default.
• W2089973243 hasConcept C118892022 @default.
• W2089973243 hasConcept C123894998 @default.
• W2089973243 hasConcept C143065580 @default.
• W2089973243 hasConcept C1491633281 @default.
• W2089973243 hasConcept C168609215 @default.
• W2089973243 hasConcept C170493617 @default.
• W2089973243 hasConcept C24530287 @default.
• W2089973243 hasConcept C40479148 @default.
• W2089973243 hasConcept C40767141 @default.
• W2089973243 hasConcept C41625074 @default.
• W2089973243 hasConcept C54355233 @default.
• W2089973243 hasConcept C79879829 @default.
• W2089973243 hasConcept C86339819 @default.
• W2089973243 hasConcept C86803240 @default.
• W2089973243 hasConcept C92488253 @default.
• W2089973243 hasConcept C95444343 @default.
• W2089973243 hasConceptScore W2089973243C104317684 @default.
• W2089973243 hasConceptScore W2089973243C118892022 @default.

• next