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- W2089974503 abstract "La protéine S-100 β est une protéine synthétisée physiologiquement par les cellules astrogliales et les cellules de la gaine de Schwann, appartenant à la grande famille des protéines S-100 de fixation du calcium intracytosolique. Cette protéine est multifonctionnelle puisqu’elle exerce également des fonctions extracellulaires, en particulier sur les neurones, en agissant sur la croissance neuritique ou en induisant leur apoptose. La protéine S-100 β constitue un marqueur biologique de pathologies neurologiques ou d’atteintes lésionnelles du tissu cérébral. Son expression par les mélanocytes tumoraux, en fait également un marqueur important du mélanome malin. S-100 β protein is a constitutive protein of glial cells, whose physiological functions are both intracellular, i.e. the intracellular calcium binding, and extracellular, e.g. by promoting neuritic proliferation and/or neuronal apoptosis. Due to specificity of its cellular expression, S-100 β protein could serve as a biological marker of neurological disorders, such as ischemic or haemorragic stroke, Alzheimer disease or brain damage occurring after surgical events. Because of the expression of this protein by tumoral, S-100 β protein also constitutes a pronostic marker of malignant melanoma." @default.
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- W2089974503 date "2002-10-01" @default.
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- W2089974503 title "Physiopathologie de la protéine S-100 β : intérêt de son dosage en biologie clinique" @default.
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- W2089974503 doi "https://doi.org/10.1016/s0923-2532(02)01210-3" @default.
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