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• W2089983463 abstract "B lymphocytes express the nonclassical class II molecule HLA-DO, which modulates the peptide loading activity of HLA-DM in the endocytic pathway. Binding to HLA-DM is required for HLA-DO to egress from the endoplasmic reticulum (ER). To gain insights into the mode of action of DO and on the role of DM in ER release, we sought to identify DM-binding residues on DO. Our results show that DOα encompasses the binding site for HLA-DM. More specifically, mutation of residue DOα41 on an exposed lateral loop of the α1 domain affects the binding to DM, ER egress, and activity of DO. Using a series of chimeric DR/DO molecules, we confirmed the role of the α chain and established that a second DM-binding region is located C-terminal to the DOα80 residue, most probably in the α2 domain. Interestingly, after mutation of a buried proline (α11) on the floor of the putative peptide-binding groove, HLA-DO remained functional but became independent of HLA-DM for ER egress and intracellular trafficking. Collectively, these results suggest that the binding of HLA-DM to DOα allows the complex to egress from the ER by stabilizing intramolecular contacts between the N-terminal antiparallel β-strands of the DOαβ heterodimer." @default.
• W2089983463 created "2016-06-24" @default.
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• W2089983463 date "2005-04-22" @default.
• W2089983463 modified "2023-10-14" @default.
• W2089983463 title "A point mutation in the groove of HLA-DO allows egress from the endoplasmic reticulum independent of HLA-DM" @default.
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• W2089983463 doi "https://doi.org/10.1073/pnas.0500853102" @default.
• W2089983463 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1088373" @default.
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• W2089983463 hasPublicationYear "2005" @default.
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