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- W2089985004 abstract "As more and more protein structures are determined and applied to drug manufacture, there is increasing interest in studying their stability. In this study, the stochastic moments (SRπk) of 53 Arc repressor mutants were introduced as molecular descriptors modeling protein stability. The Linear Discriminant Analysis model developed correctly classified 43 out of 53, 81.13% of proteins according to their thermal stability. More specifically, the model classified 20/28 (71.4%) proteins with near wild-type stability and 23/25 (92%) proteins with reduced stability. Moreover, validation of the model was carried out by re-substitution procedures (81.0%). In addition, the stochastic moments based model compared favorably with respect to others based on physicochemical and geometric parameters such as D-Fire potential, surface area, volume, partition coefficient, and molar refractivity, which presented less than 77% of accuracy. This result illustrates the possibilities of the stochastic moments’ method for the study of bioorganic and medicinal chemistry relevant proteins." @default.
- W2089985004 created "2016-06-24" @default.
- W2089985004 creator A5013497733 @default.
- W2089985004 creator A5069617183 @default.
- W2089985004 creator A5070602119 @default.
- W2089985004 date "2005-01-01" @default.
- W2089985004 modified "2023-10-18" @default.
- W2089985004 title "Predicting stability of Arc repressor mutants with protein stochastic moments" @default.
- W2089985004 cites W1499516803 @default.
- W2089985004 cites W1549949328 @default.
- W2089985004 cites W1551123031 @default.
- W2089985004 cites W1561712938 @default.
- W2089985004 cites W1616975058 @default.
- W2089985004 cites W1731585115 @default.
- W2089985004 cites W1963733856 @default.
- W2089985004 cites W1968673134 @default.
- W2089985004 cites W1971075690 @default.
- W2089985004 cites W1974500983 @default.
- W2089985004 cites W1974605793 @default.
- W2089985004 cites W1974697910 @default.
- W2089985004 cites W1980266776 @default.
- W2089985004 cites W1980497258 @default.
- W2089985004 cites W1981221782 @default.
- W2089985004 cites W1982580056 @default.
- W2089985004 cites W1985533311 @default.
- W2089985004 cites W1987181947 @default.
- W2089985004 cites W1987588498 @default.
- W2089985004 cites W1987713050 @default.
- W2089985004 cites W1990748933 @default.
- W2089985004 cites W1990905078 @default.
- W2089985004 cites W1995221123 @default.
- W2089985004 cites W2002503642 @default.
- W2089985004 cites W2004331331 @default.
- W2089985004 cites W2008489796 @default.
- W2089985004 cites W2009519841 @default.
- W2089985004 cites W2010708237 @default.
- W2089985004 cites W2012359195 @default.
- W2089985004 cites W2013333835 @default.
- W2089985004 cites W2017013630 @default.
- W2089985004 cites W2018230795 @default.
- W2089985004 cites W2019447526 @default.
- W2089985004 cites W2022288137 @default.
- W2089985004 cites W2022669488 @default.
- W2089985004 cites W2023703189 @default.
- W2089985004 cites W2025046262 @default.
- W2089985004 cites W2026600362 @default.
- W2089985004 cites W2028358481 @default.
- W2089985004 cites W2028597865 @default.
- W2089985004 cites W2031006390 @default.
- W2089985004 cites W2036674572 @default.
- W2089985004 cites W2046915430 @default.
- W2089985004 cites W2049288455 @default.
- W2089985004 cites W2050282655 @default.
- W2089985004 cites W2052718768 @default.
- W2089985004 cites W2058286156 @default.
- W2089985004 cites W2058556255 @default.
- W2089985004 cites W2062388969 @default.
- W2089985004 cites W2064589158 @default.
- W2089985004 cites W2065434265 @default.
- W2089985004 cites W2072705466 @default.
- W2089985004 cites W2074890905 @default.
- W2089985004 cites W2075145136 @default.
- W2089985004 cites W2075820422 @default.
- W2089985004 cites W2076592170 @default.
- W2089985004 cites W2079969270 @default.
- W2089985004 cites W2083977672 @default.
- W2089985004 cites W2085341172 @default.
- W2089985004 cites W2088437415 @default.
- W2089985004 cites W2092057251 @default.
- W2089985004 cites W2094719223 @default.
- W2089985004 cites W2097050692 @default.
- W2089985004 cites W2100851422 @default.
- W2089985004 cites W2102122585 @default.
- W2089985004 cites W2114304598 @default.
- W2089985004 cites W2125677968 @default.
- W2089985004 cites W2133263603 @default.
- W2089985004 cites W2133335870 @default.
- W2089985004 cites W2140713760 @default.
- W2089985004 cites W2152180708 @default.
- W2089985004 cites W2156455458 @default.
- W2089985004 cites W2160979370 @default.
- W2089985004 cites W2164412882 @default.
- W2089985004 cites W2167666169 @default.
- W2089985004 cites W2172565224 @default.
- W2089985004 cites W2203679171 @default.
- W2089985004 cites W2219114748 @default.
- W2089985004 cites W2221809994 @default.
- W2089985004 cites W2329686304 @default.
- W2089985004 cites W4238204188 @default.
- W2089985004 cites W54822236 @default.
- W2089985004 doi "https://doi.org/10.1016/j.bmc.2004.10.024" @default.
- W2089985004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15598555" @default.
- W2089985004 hasPublicationYear "2005" @default.
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