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• W2089985483 abstract "Lung inflammation in cystic fibrosis (CF) is associated with an increased release from activated neutrophils of oxidants and proteinases. Free radical generation is not efficiently neutralized, and the major anti-proteinase,α1-proteinase inhibitor (α1-PI) is thought to be oxidatively inactivated. We hypothesized that enhanced antioxidant protection could represent an additional long-term strategy to attentuate the host inflammatory response. The effect on plasma neutrophil elastase/α1-PI (NE/α1-PI) complex levels (as a marker of lung inflammation) and plasma malondialdehyde concentrations (as a marker of lipid peroxidation) of additional oral β-carotene supplementation was studied in 33 CF patients who had already received long-term vitamin E supplementation. In the presence of a more than 10-fold increase in plasma β-carotene concentrations (mean ± SEM) (0.09± 0.01 to 1.07 ± 0.19 μmol/L; p < 0.0001), a small increase in plasma α-tocopherol concentrations (23.8 ± 1.31 to 28.4 ± 1.81 μmol/L; p = 0.02), and a more than 50% decrease in plasma malondialdehyde concentrations (1.00 ± 0.07 to 0.46± 0.03 μmol/L; p < 0.0001), plasma NE/α1-PI complex levels decreased from 102.2 ± 16.0 to 83.0 ± 10.4 μg/L; (p = 0.02). Plasma retinol concentrations increased (1.05 ± 0.06 to 1.23 ± 0.07 μmol/L;p = 0.0001) due to conversion of β-carotene to retinol, which could have contributed to the decrease in NE/α1-PI complex levels. Based on these results, we speculate that efficient antioxidant supplementation could attenuate lung inflammation in CF." @default.
• W2089985483 created "2016-06-24" @default.
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• W2089985483 date "1996-07-01" @default.
• W2089985483 modified "2023-10-01" @default.
• W2089985483 title "Neutrophil Elastase/α1-Proteinase Inhibitor Complex Levels Decrease in Plasma of Cystic Fibrosis Patients during Long-Term Oral β-Carotene Supplementation1" @default.
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• W2089985483 doi "https://doi.org/10.1203/00006450-199607000-00022" @default.
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