Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090000863> ?p ?o ?g. }
- W2090000863 abstract "Intermediate neural progenitor cells (INPs) need to avoid differentiation and cell cycle exit while maintaining restricted developmental potential, but mechanisms preventing differentiation and cell cycle exit of INPs are not well understood. In this study, we report that the Drosophila homolog of mammalian Sp8 transcription factor Buttonhead (Btd) prevents premature differentiation and cell cycle exit of INPs in Drosophila larval type II neuroblast (NB) lineages. We show that the loss of Btd leads to elimination of mature INPs due to premature differentiation of INPs into terminally dividing ganglion mother cells. We provide evidence to demonstrate that Btd prevents the premature differentiation by suppressing the expression of the homeodomain protein Prospero in immature INPs. We further show that Btd functions cooperatively with the Ets transcription factor Pointed P1 to promote the generation of INPs. Thus, our work reveals a critical mechanism that prevents premature differentiation and cell cycle exit of Drosophila INPs." @default.
- W2090000863 created "2016-06-24" @default.
- W2090000863 creator A5014980845 @default.
- W2090000863 creator A5050161555 @default.
- W2090000863 creator A5052813770 @default.
- W2090000863 creator A5056522320 @default.
- W2090000863 creator A5058761429 @default.
- W2090000863 creator A5074999356 @default.
- W2090000863 creator A5091586700 @default.
- W2090000863 date "2014-10-06" @default.
- W2090000863 modified "2023-09-25" @default.
- W2090000863 title "The Drosophila Sp8 transcription factor Buttonhead prevents premature differentiation of intermediate neural progenitors" @default.
- W2090000863 cites W1578975528 @default.
- W2090000863 cites W1923305081 @default.
- W2090000863 cites W1956275602 @default.
- W2090000863 cites W1968674209 @default.
- W2090000863 cites W1970862055 @default.
- W2090000863 cites W1972431153 @default.
- W2090000863 cites W1972776308 @default.
- W2090000863 cites W1978648122 @default.
- W2090000863 cites W1978717021 @default.
- W2090000863 cites W1981336776 @default.
- W2090000863 cites W1987582818 @default.
- W2090000863 cites W1988754143 @default.
- W2090000863 cites W1990943845 @default.
- W2090000863 cites W1991770658 @default.
- W2090000863 cites W2000345419 @default.
- W2090000863 cites W2001515992 @default.
- W2090000863 cites W2006229889 @default.
- W2090000863 cites W2010677999 @default.
- W2090000863 cites W2010994321 @default.
- W2090000863 cites W2012118125 @default.
- W2090000863 cites W2021892293 @default.
- W2090000863 cites W2026998481 @default.
- W2090000863 cites W2031140437 @default.
- W2090000863 cites W2032455771 @default.
- W2090000863 cites W2036709952 @default.
- W2090000863 cites W2048135890 @default.
- W2090000863 cites W2049520895 @default.
- W2090000863 cites W2065387800 @default.
- W2090000863 cites W2072710787 @default.
- W2090000863 cites W2085806268 @default.
- W2090000863 cites W2092900311 @default.
- W2090000863 cites W2093786414 @default.
- W2090000863 cites W2100247997 @default.
- W2090000863 cites W2101983707 @default.
- W2090000863 cites W2104917184 @default.
- W2090000863 cites W2107227145 @default.
- W2090000863 cites W2107291116 @default.
- W2090000863 cites W2110128697 @default.
- W2090000863 cites W2112342460 @default.
- W2090000863 cites W2116396547 @default.
- W2090000863 cites W2119836524 @default.
- W2090000863 cites W2120613121 @default.
- W2090000863 cites W2121824796 @default.
- W2090000863 cites W2129422654 @default.
- W2090000863 cites W2137654905 @default.
- W2090000863 cites W2138139505 @default.
- W2090000863 cites W2148120557 @default.
- W2090000863 cites W2154240765 @default.
- W2090000863 cites W2154262793 @default.
- W2090000863 cites W2155230919 @default.
- W2090000863 cites W2156200367 @default.
- W2090000863 cites W2157480976 @default.
- W2090000863 cites W2169786878 @default.
- W2090000863 cites W2172266256 @default.
- W2090000863 cites W2188111937 @default.
- W2090000863 doi "https://doi.org/10.7554/elife.03596" @default.
- W2090000863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4221738" @default.
- W2090000863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25285448" @default.
- W2090000863 hasPublicationYear "2014" @default.
- W2090000863 type Work @default.
- W2090000863 sameAs 2090000863 @default.
- W2090000863 citedByCount "24" @default.
- W2090000863 countsByYear W20900008632014 @default.
- W2090000863 countsByYear W20900008632015 @default.
- W2090000863 countsByYear W20900008632016 @default.
- W2090000863 countsByYear W20900008632017 @default.
- W2090000863 countsByYear W20900008632018 @default.
- W2090000863 countsByYear W20900008632019 @default.
- W2090000863 countsByYear W20900008632020 @default.
- W2090000863 countsByYear W20900008632021 @default.
- W2090000863 countsByYear W20900008632022 @default.
- W2090000863 crossrefType "journal-article" @default.
- W2090000863 hasAuthorship W2090000863A5014980845 @default.
- W2090000863 hasAuthorship W2090000863A5050161555 @default.
- W2090000863 hasAuthorship W2090000863A5052813770 @default.
- W2090000863 hasAuthorship W2090000863A5056522320 @default.
- W2090000863 hasAuthorship W2090000863A5058761429 @default.
- W2090000863 hasAuthorship W2090000863A5074999356 @default.
- W2090000863 hasAuthorship W2090000863A5091586700 @default.
- W2090000863 hasBestOaLocation W20900008631 @default.
- W2090000863 hasConcept C104317684 @default.
- W2090000863 hasConcept C121587040 @default.
- W2090000863 hasConcept C136834591 @default.
- W2090000863 hasConcept C148738053 @default.
- W2090000863 hasConcept C1491633281 @default.
- W2090000863 hasConcept C15729860 @default.
- W2090000863 hasConcept C201750760 @default.
- W2090000863 hasConcept C28328180 @default.