FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090000992> ?p ?o ?g. }

• W2090000992 abstract "Malignant peripheral nerve sheath tumors (MPNST) are a type of soft tissue sarcoma that can be associated with germline mutations in Neurofibromatosis type 1 (NF1) or may occur sporadically. Although the etiology of MPNST is poorly understood, it is clear that a loss of function of the NF1 gene, encoding a Ras-GAP, is an important factor in the tumorigenesis of the inherited form of MPNST. Tumor latency in NF1 patients suggests that additional mutational events are probably required for malignancy. In order to define oncogene mutations associated with 5 MPNST cell lines, we assayed the 238 most frequent mutations in 19 commonly activated oncogenes using mass spectroscopy-based analysis. All 238 mutation sites in the assayed oncogenes were determined to harbor only wild-type sequences. These data suggest that hyperactive Ras resulting from the loss function of neurofibromin may be sufficient to set up the direction of malignant transformation of Schwann cells to MPNST." @default.
• W2090000992 created "2016-06-24" @default.
• W2090000992 creator A5065937259 @default.
• W2090000992 creator A5069778809 @default.
• W2090000992 creator A5087997765 @default.
• W2090000992 date "2012-01-01" @default.
• W2090000992 modified "2023-09-28" @default.
• W2090000992 title "Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy" @default.
• W2090000992 cites W1559883839 @default.
• W2090000992 cites W157286469 @default.
• W2090000992 cites W1989773675 @default.
• W2090000992 cites W1996625586 @default.
• W2090000992 cites W2007927189 @default.
• W2090000992 cites W2008597053 @default.
• W2090000992 cites W2020231002 @default.
• W2090000992 cites W2021192134 @default.
• W2090000992 cites W202730752 @default.
• W2090000992 cites W2044514965 @default.
• W2090000992 cites W2047818921 @default.
• W2090000992 cites W2053442386 @default.
• W2090000992 cites W2054674800 @default.
• W2090000992 cites W2058188673 @default.
• W2090000992 cites W2060632243 @default.
• W2090000992 cites W2068718620 @default.
• W2090000992 cites W2069050357 @default.
• W2090000992 cites W2069886811 @default.
• W2090000992 cites W2120420804 @default.
• W2090000992 cites W2121651129 @default.
• W2090000992 cites W2121733985 @default.
• W2090000992 cites W2130521145 @default.
• W2090000992 cites W2130949666 @default.
• W2090000992 cites W2132630169 @default.
• W2090000992 cites W2134665304 @default.
• W2090000992 cites W2137036286 @default.
• W2090000992 cites W2144501719 @default.
• W2090000992 cites W2149500996 @default.
• W2090000992 cites W2154151857 @default.
• W2090000992 cites W2187206683 @default.
• W2090000992 cites W2468354385 @default.
• W2090000992 doi "https://doi.org/10.4137/tog.s8830" @default.
• W2090000992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3273949" @default.
• W2090000992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22346343" @default.
• W2090000992 hasPublicationYear "2012" @default.
• W2090000992 type Work @default.
• W2090000992 sameAs 2090000992 @default.
• W2090000992 citedByCount "13" @default.
• W2090000992 countsByYear W20900009922012 @default.
• W2090000992 countsByYear W20900009922013 @default.
• W2090000992 countsByYear W20900009922014 @default.
• W2090000992 countsByYear W20900009922016 @default.
• W2090000992 countsByYear W20900009922017 @default.
• W2090000992 countsByYear W20900009922018 @default.
• W2090000992 countsByYear W20900009922019 @default.
• W2090000992 countsByYear W20900009922020 @default.
• W2090000992 countsByYear W20900009922021 @default.
• W2090000992 countsByYear W20900009922022 @default.
• W2090000992 crossrefType "journal-article" @default.
• W2090000992 hasAuthorship W2090000992A5065937259 @default.
• W2090000992 hasAuthorship W2090000992A5069778809 @default.
• W2090000992 hasAuthorship W2090000992A5087997765 @default.
• W2090000992 hasBestOaLocation W20900009922 @default.
• W2090000992 hasConcept C104317684 @default.
• W2090000992 hasConcept C109825262 @default.
• W2090000992 hasConcept C13514818 @default.
• W2090000992 hasConcept C142724271 @default.
• W2090000992 hasConcept C1491633281 @default.
• W2090000992 hasConcept C170932241 @default.
• W2090000992 hasConcept C2778173781 @default.
• W2090000992 hasConcept C2778256501 @default.
• W2090000992 hasConcept C2778984943 @default.
• W2090000992 hasConcept C2779399171 @default.
• W2090000992 hasConcept C2781018059 @default.
• W2090000992 hasConcept C2910357046 @default.
• W2090000992 hasConcept C29537977 @default.
• W2090000992 hasConcept C31033888 @default.
• W2090000992 hasConcept C501734568 @default.
• W2090000992 hasConcept C502942594 @default.
• W2090000992 hasConcept C54355233 @default.
• W2090000992 hasConcept C555283112 @default.
• W2090000992 hasConcept C71924100 @default.
• W2090000992 hasConcept C86803240 @default.
• W2090000992 hasConceptScore W2090000992C104317684 @default.
• W2090000992 hasConceptScore W2090000992C109825262 @default.
• W2090000992 hasConceptScore W2090000992C13514818 @default.
• W2090000992 hasConceptScore W2090000992C142724271 @default.
• W2090000992 hasConceptScore W2090000992C1491633281 @default.
• W2090000992 hasConceptScore W2090000992C170932241 @default.
• W2090000992 hasConceptScore W2090000992C2778173781 @default.
• W2090000992 hasConceptScore W2090000992C2778256501 @default.
• W2090000992 hasConceptScore W2090000992C2778984943 @default.
• W2090000992 hasConceptScore W2090000992C2779399171 @default.
• W2090000992 hasConceptScore W2090000992C2781018059 @default.
• W2090000992 hasConceptScore W2090000992C2910357046 @default.
• W2090000992 hasConceptScore W2090000992C29537977 @default.
• W2090000992 hasConceptScore W2090000992C31033888 @default.
• W2090000992 hasConceptScore W2090000992C501734568 @default.
• W2090000992 hasConceptScore W2090000992C502942594 @default.
• W2090000992 hasConceptScore W2090000992C54355233 @default.
• W2090000992 hasConceptScore W2090000992C555283112 @default.
• W2090000992 hasConceptScore W2090000992C71924100 @default.

• next