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- W2090005554 abstract "During the ESR spectroscopic titration of nitrosyl-iron bleomycin, ONFe(II)Blm, with DNA, its metal domain undergoes a change in environment as the DNA base pair to drug ratio increases to 50 to 1. The 15NO stretching frequency of ONFe(II)Blm occurs at 1589 cm−1, similar to that for nitrosyl hemoglobin and myoglobin. Upon addition of DNA (3 base pairs per drug molecule), this vibration is substantially broadened. Injection of O2 into a solution of ONFe(II)BlmDNA converts the ESR signal of the nitrosyl species to low spin Fe(III) BlmDNA. NO is largely oxidized to NO2−. The combination of these products suggests that the initial reaction of ONFe(II)Blm with O2 generates Fe(III)Blm and peroxynitrite, O2NO−. If peroxynitrite is formed in the reaction, it does not cause detectable DNA damage. The structural integrity of a supercoiled DNA plasmid, pBR322, is not compromised and no base propenals are produced during this reaction." @default.
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- W2090005554 date "1995-12-01" @default.
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- W2090005554 title "Reaction of nitric oxide with iron bleomycin bound to DNA: properties of the nitrosyl adduct and its reaction with O2" @default.
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- W2090005554 doi "https://doi.org/10.1016/0020-1693(95)04580-5" @default.
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