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- W2090015512 abstract "To compare health care outcomes between hepatitis c virus (HCV) patients who were prescribed pegylated interferon-alpha with or without ribavirin to those who were not prescribed these medications. Using the Turkish National Heath Insurance Database (2009-2011), HCV patients were identified using International Classification of Disease, 10th Revision, Clinical Modification codes. The first prescription date was designated as the index date. Mortality and hepatocellular carcinoma (HCC) rates and health care costs of treated and untreated patients were compared using propensity score matching. Baseline demographic and clinical factors were controlled in the models. Subgroup analysis was conducted for patient groups with and without a cirrhosis diagnosis. A total 12,990 patients, of whom 2,467 were diagnosed with cirrhosis, were included in the study. 12.2% of the overall population was treated for HCV. Treated patients were younger, less likely to reside in Central or Eastern Anatolia and less likely to have comorbidities. After adjusting for baseline demographic and clinical factors, mortality rates (2.27% vs. 5.31%, p<0.001) and HCC rates (0.69% vs. 1.96%, p<0.001) were significantly lower for treated HCV patients. The differences were more significant among cirrhosis patients. Total risk-adjusted annual costs were significantly higher for treated patients (€6,172 vs. €1,680, p<0.001), mainly due to higher pharmaceutical costs (€4,918 vs. €583, p<0.001). HCV treatment, although costly, significantly reduces mortality and HCC rates in Turkey." @default.
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- W2090015512 date "2014-11-01" @default.
- W2090015512 modified "2023-10-16" @default.
- W2090015512 title "Economic Burden and Complications of Hepatitis C Virus Patients With and Without Peginterferon and Ribavirin Treatment in Turkey" @default.
- W2090015512 doi "https://doi.org/10.1016/j.jval.2014.08.2490" @default.
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