FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090020543> ?p ?o ?g. }

• W2090020543 endingPage "2155" @default.
• W2090020543 startingPage "2150" @default.
• W2090020543 abstract "ABSTRACT Members of the genus Acanthamoeba are facultative pathogens of humans, causing a sight-threatening keratitis and a fatal encephalitis. We have targeted myosin-IC by using small interfering RNA (siRNA) silencing as a therapeutic approach, since it is known that the function of this protein is vital for the amoeba. In this work, specific siRNAs against the Acanthamoeba myosin-IC gene were developed. Treated and control amoebae were cultured in growth and encystment media to evaluate the induced effects after myosin-IC gene knockdown, as we have anticipated that cyst formation may be impaired. The effects of myosin-IC gene silencing were inhibition of cyst formation, inhibition of completion of cytokinesis, inhibition of osmoregulation under osmotic stress conditions, and death of the amoebae. The finding that myosin-IC silencing caused incompletion of cytokinesis is in agreement with earlier suggestions that the protein plays a role in cell locomotion, which is necessary to pull daughter cells apart after mitosis in a process known as “traction-mediated cytokinesis”. We conclude that myosin-IC is a very promising potential drug target for the development of much-needed antiamoebal drugs and that it should be further exploited for Acanthamoeba therapy." @default.
• W2090020543 created "2016-06-24" @default.
• W2090020543 creator A5012307289 @default.
• W2090020543 creator A5022387890 @default.
• W2090020543 creator A5023623503 @default.
• W2090020543 creator A5027350060 @default.
• W2090020543 creator A5049471662 @default.
• W2090020543 creator A5063263007 @default.
• W2090020543 creator A5084234518 @default.
• W2090020543 date "2014-04-01" @default.
• W2090020543 modified "2023-10-18" @default.
• W2090020543 title "Evaluation of Acanthamoeba Myosin-IC as a Potential Therapeutic Target" @default.
• W2090020543 cites W1503263897 @default.
• W2090020543 cites W1523812006 @default.
• W2090020543 cites W1651271817 @default.
• W2090020543 cites W1979320189 @default.
• W2090020543 cites W2000940439 @default.
• W2090020543 cites W2004416463 @default.
• W2090020543 cites W2014536973 @default.
• W2090020543 cites W2016208033 @default.
• W2090020543 cites W2020238073 @default.
• W2090020543 cites W2030297678 @default.
• W2090020543 cites W2037968918 @default.
• W2090020543 cites W2039631515 @default.
• W2090020543 cites W2042567750 @default.
• W2090020543 cites W2084281420 @default.
• W2090020543 cites W2096296061 @default.
• W2090020543 cites W2107008313 @default.
• W2090020543 cites W2117090318 @default.
• W2090020543 cites W2127016760 @default.
• W2090020543 cites W2134843408 @default.
• W2090020543 cites W2141231972 @default.
• W2090020543 cites W2160013389 @default.
• W2090020543 cites W2168637840 @default.
• W2090020543 cites W2178001152 @default.
• W2090020543 cites W2437808312 @default.
• W2090020543 doi "https://doi.org/10.1128/aac.01199-13" @default.
• W2090020543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4023789" @default.
• W2090020543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24468784" @default.
• W2090020543 hasPublicationYear "2014" @default.
• W2090020543 type Work @default.
• W2090020543 sameAs 2090020543 @default.
• W2090020543 citedByCount "10" @default.
• W2090020543 countsByYear W20900205432015 @default.
• W2090020543 countsByYear W20900205432016 @default.
• W2090020543 countsByYear W20900205432019 @default.
• W2090020543 countsByYear W20900205432020 @default.
• W2090020543 countsByYear W20900205432022 @default.
• W2090020543 countsByYear W20900205432023 @default.
• W2090020543 crossrefType "journal-article" @default.
• W2090020543 hasAuthorship W2090020543A5012307289 @default.
• W2090020543 hasAuthorship W2090020543A5022387890 @default.
• W2090020543 hasAuthorship W2090020543A5023623503 @default.
• W2090020543 hasAuthorship W2090020543A5027350060 @default.
• W2090020543 hasAuthorship W2090020543A5049471662 @default.
• W2090020543 hasAuthorship W2090020543A5063263007 @default.
• W2090020543 hasAuthorship W2090020543A5084234518 @default.
• W2090020543 hasBestOaLocation W20900205431 @default.
• W2090020543 hasConcept C104317684 @default.
• W2090020543 hasConcept C119056186 @default.
• W2090020543 hasConcept C1491633281 @default.
• W2090020543 hasConcept C173396325 @default.
• W2090020543 hasConcept C2778868110 @default.
• W2090020543 hasConcept C45472230 @default.
• W2090020543 hasConcept C54355233 @default.
• W2090020543 hasConcept C6997183 @default.
• W2090020543 hasConcept C85813293 @default.
• W2090020543 hasConcept C86803240 @default.
• W2090020543 hasConcept C89423630 @default.
• W2090020543 hasConcept C93304396 @default.
• W2090020543 hasConcept C95444343 @default.
• W2090020543 hasConceptScore W2090020543C104317684 @default.
• W2090020543 hasConceptScore W2090020543C119056186 @default.
• W2090020543 hasConceptScore W2090020543C1491633281 @default.
• W2090020543 hasConceptScore W2090020543C173396325 @default.
• W2090020543 hasConceptScore W2090020543C2778868110 @default.
• W2090020543 hasConceptScore W2090020543C45472230 @default.
• W2090020543 hasConceptScore W2090020543C54355233 @default.
• W2090020543 hasConceptScore W2090020543C6997183 @default.
• W2090020543 hasConceptScore W2090020543C85813293 @default.
• W2090020543 hasConceptScore W2090020543C86803240 @default.
• W2090020543 hasConceptScore W2090020543C89423630 @default.
• W2090020543 hasConceptScore W2090020543C93304396 @default.
• W2090020543 hasConceptScore W2090020543C95444343 @default.
• W2090020543 hasIssue "4" @default.
• W2090020543 hasLocation W20900205431 @default.
• W2090020543 hasLocation W20900205432 @default.
• W2090020543 hasLocation W20900205433 @default.
• W2090020543 hasLocation W20900205434 @default.
• W2090020543 hasOpenAccess W2090020543 @default.
• W2090020543 hasPrimaryLocation W20900205431 @default.
• W2090020543 hasRelatedWork W1975773567 @default.
• W2090020543 hasRelatedWork W1982402014 @default.
• W2090020543 hasRelatedWork W2087463186 @default.
• W2090020543 hasRelatedWork W2110793252 @default.
• W2090020543 hasRelatedWork W2140319446 @default.
• W2090020543 hasRelatedWork W2140725073 @default.
• W2090020543 hasRelatedWork W2335798953 @default.

• next