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- W2090030205 abstract "Abstract Preterm infants have a high rate of neurodevelopmental handicap. Recent imaging studies have revealed that adverse outcomes are strongly associated with reduced brain growth and neural complexity in later life. Increasing data suggest that these chronic deficits primarily reflect acute neuronal and glial injury sustained during adverse in utero events, such as exposure to severe hypoxia–ischemia and inflammation. In the present review we examine recent evidence that this chronic impairment is partly due to upregulation of physiological apoptosis, related to input deprivation, and output isolation secondary to acute white and gray matter damage and axonal injury. However, progenitor cells in the subventricular zone (SVZ) are also vulnerable to injury, and loss of part of this critical population likely further compromises brain development. Based on these concepts the impact of proposed interventions such as induced hypothermia and endogenous growth factors are likely to be complex, but potentially offer focused ways of improving the outcomes of premature birth. Birth Defects Research (Part C) 81:163–176, 2007. © 2007 Wiley‐Liss, Inc." @default.
- W2090030205 created "2016-06-24" @default.
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- W2090030205 date "2007-09-01" @default.
- W2090030205 modified "2023-10-16" @default.
- W2090030205 title "Destruction and reconstruction: Hypoxia and the developing brain" @default.
- W2090030205 cites W1500669132 @default.
- W2090030205 cites W1515706525 @default.
- W2090030205 cites W1519250999 @default.
- W2090030205 cites W1565204319 @default.
- W2090030205 cites W1583506863 @default.
- W2090030205 cites W1589449569 @default.
- W2090030205 cites W1653076540 @default.
- W2090030205 cites W1665470030 @default.
- W2090030205 cites W1758833828 @default.
- W2090030205 cites W1864437270 @default.
- W2090030205 cites W1896545635 @default.
- W2090030205 cites W1929957938 @default.
- W2090030205 cites W1963663815 @default.
- W2090030205 cites W1964439184 @default.
- W2090030205 cites W1965899063 @default.
- W2090030205 cites W1967937733 @default.
- W2090030205 cites W1969046656 @default.
- W2090030205 cites W1973882764 @default.
- W2090030205 cites W1974034780 @default.
- W2090030205 cites W1974604292 @default.
- W2090030205 cites W1980471744 @default.
- W2090030205 cites W1980852682 @default.
- W2090030205 cites W1981284566 @default.
- W2090030205 cites W1981367767 @default.
- W2090030205 cites W1982076869 @default.
- W2090030205 cites W1983054342 @default.
- W2090030205 cites W1987126916 @default.
- W2090030205 cites W1987624712 @default.
- W2090030205 cites W1990523080 @default.
- W2090030205 cites W1993097534 @default.
- W2090030205 cites W1994024874 @default.
- W2090030205 cites W1995483829 @default.
- W2090030205 cites W1996527158 @default.
- W2090030205 cites W1997851802 @default.
- W2090030205 cites W1997946324 @default.
- W2090030205 cites W1999495417 @default.
- W2090030205 cites W1999932156 @default.
- W2090030205 cites W2002381210 @default.
- W2090030205 cites W2002787064 @default.
- W2090030205 cites W2004093508 @default.
- W2090030205 cites W2005272267 @default.
- W2090030205 cites W2007629861 @default.
- W2090030205 cites W2007644749 @default.
- W2090030205 cites W2011284361 @default.
- W2090030205 cites W2011557383 @default.
- W2090030205 cites W2011792758 @default.
- W2090030205 cites W2012893265 @default.
- W2090030205 cites W2013774253 @default.
- W2090030205 cites W2014547350 @default.
- W2090030205 cites W2014919748 @default.
- W2090030205 cites W2015424325 @default.
- W2090030205 cites W2016894228 @default.
- W2090030205 cites W2018118665 @default.
- W2090030205 cites W2019546613 @default.
- W2090030205 cites W2020315449 @default.
- W2090030205 cites W2020649652 @default.
- W2090030205 cites W2020680765 @default.
- W2090030205 cites W2021399360 @default.
- W2090030205 cites W2021721582 @default.
- W2090030205 cites W2022381785 @default.
- W2090030205 cites W2022568291 @default.
- W2090030205 cites W2023693164 @default.
- W2090030205 cites W2031168397 @default.
- W2090030205 cites W2034915619 @default.
- W2090030205 cites W2036110820 @default.
- W2090030205 cites W2036158708 @default.
- W2090030205 cites W2037085141 @default.
- W2090030205 cites W2038977659 @default.
- W2090030205 cites W2039355845 @default.
- W2090030205 cites W2039992040 @default.
- W2090030205 cites W2041033879 @default.
- W2090030205 cites W2043820074 @default.
- W2090030205 cites W2043950478 @default.
- W2090030205 cites W2044570977 @default.
- W2090030205 cites W2044947593 @default.
- W2090030205 cites W2045219454 @default.
- W2090030205 cites W2046393461 @default.
- W2090030205 cites W2047531540 @default.
- W2090030205 cites W2051720483 @default.
- W2090030205 cites W2052180393 @default.
- W2090030205 cites W2052431024 @default.
- W2090030205 cites W2053851470 @default.
- W2090030205 cites W2054375036 @default.
- W2090030205 cites W2056985474 @default.
- W2090030205 cites W2057562617 @default.
- W2090030205 cites W2059082884 @default.