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• W2090032009 startingPage "e89427" @default.
• W2090032009 abstract "Streptococcus pneumoniae requires manganese for colonization of the human host, but the underlying molecular basis for this requirement has not been elucidated. Recently, it was shown that zinc could compromise manganese uptake and that zinc levels increased during infection by S. pneumoniae in all the niches that it colonized. Here we show, by quantitative means, that extracellular zinc acts in a dose dependent manner to competitively inhibit manganese uptake by S. pneumoniae, with an EC50 of 30.2 µM for zinc in cation-defined media. By exploiting the ability to directly manipulate S. pneumoniae accumulation of manganese, we analyzed the connection between manganese and superoxide dismutase (SodA), a primary source of protection for S. pneumoniae against oxidative stress. We show that manganese starvation led to a decrease in sodA transcription indicating that expression of sodA was regulated through an unknown manganese responsive pathway. Intriguingly, examination of recombinant SodA revealed that the enzyme was potentially a cambialistic superoxide dismutase with an iron/manganese cofactor. SodA was also shown to provide the majority of protection against oxidative stress as a S. pneumoniae ΔsodA mutant strain was found to be hypersensitive to oxidative stress, despite having wild-type manganese levels, indicating that the metal ion alone was not sufficiently protective. Collectively, these results provide a quantitative assessment of the competitive effect of zinc upon manganese uptake and provide a molecular basis for how extracellular zinc exerts a ‘toxic’ effect on bacterial pathogens, such as S. pneumoniae." @default.
• W2090032009 created "2016-06-24" @default.
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• W2090032009 date "2014-02-18" @default.
• W2090032009 modified "2023-10-18" @default.
• W2090032009 title "Extracellular Zinc Competitively Inhibits Manganese Uptake and Compromises Oxidative Stress Management in Streptococcus pneumoniae" @default.
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• W2090032009 doi "https://doi.org/10.1371/journal.pone.0089427" @default.
• W2090032009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3928430" @default.
• W2090032009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24558498" @default.
• W2090032009 hasPublicationYear "2014" @default.
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