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• W2090036968 abstract "We thank Fayda and Karanlik for commenting that IBCSG 23-01 provides clear level 1 evidence for omittance of axillary dissection in patients with sentinel-node micrometastatic breast cancer. Both Fayda and Karanlik, and Boyages and Winch, suggest that caution should be used in extending this conclusion to patients who have had a mastectomy. In fact, our study was restricted to patients with micrometastatic disease, and we were cautious in our conclusion and stated that: “Although numbers are small, subgroup analysis suggested that no axillary dissection might be acceptable for patients undergoing mastectomy, provided the invasive component of the breast lesion is small”. 1 Galimberti V Cole BF Zurrida S et al. Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23-01): a phase 3 randomised controlled trial. Lancet Oncol. 2013; 14: 297-305 Summary Full Text Full Text PDF PubMed Scopus (838) Google Scholar Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trialAxillary dissection could be avoided in patients with early breast cancer and limited sentinel-node involvement, thus eliminating complications of axillary surgery with no adverse effect on survival. Full-Text PDF Axillary versus sentinel-lymph-node dissection for micrometastatic breast cancerThe very clear level 1 evidence from the IBCSG 23-01 study1 further strengthens the results of the Z0011 trial2 for the omittance of axillary dissection in patients with sentinel-node micrometastatic breast cancer. Both trials included patients who mainly underwent breast-conserving treatment. Only 9% of patients in the IBCSG 23-01 trial underwent a mastectomy. Thus, whether the omittance of axillary dissection is safe in mastectomy patients with sentinel-lymph-node biopsy-proven micrometatasis is unclear. Full-Text PDF Axillary versus sentinel-lymph-node dissection for micrometastatic breast cancerGalimberti and colleagues1 argue that axillary dissection is unnecessary for some women with sentinel-node micrometastases, including those who have had a mastectomy. The investigators claim that the 2011 St Gallen Consensus Conference2 recommended against sentinel-node micrometastasis being an indication for axillary dissection, “regardless of the type of breast surgery”. In fact, the next sentence of the St Gallen report is “[no axillary dissection], based on a specific clinical trial setting, should not be extended more generally, such as to patients undergoing mastectomy”. Full-Text PDF" @default.
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• W2090036968 date "2013-06-01" @default.
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• W2090036968 title "Axillary versus sentinel-lymph-node dissection for micrometastatic breast cancer – Authors' reply" @default.
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• W2090036968 doi "https://doi.org/10.1016/s1470-2045(13)70241-9" @default.
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